81707-12-2Relevant academic research and scientific papers
An environmentally friendly synthesis of functionalized indanes using electrochemical cyclization of ortho-halo-substituted homoallyl ethers and esters
Olivero, Sandra,Perriot, Rodolphe,Du?ach, Elisabet,Baru, Ashvin R.,Bell, Eric D.,Mohan, Ram S.
, p. 2021 - 2026 (2006)
The electrochemical cyclization of a series of ortho-halo-substituted homoallyl ethers and esters to functionalized indanes catalyzed by Ni(II) catalyst precursors derived from Ni(cyclam)Br2, (cyclam = 1,4,8,11-tetraazacyclotetradecane) and Ni(tmc)Br2, (tmc = 1,4,8,11-tetramethyl-1,4,8,11-tetraazacyclotetradecane) is reported. The starting homoallyl ethers were synthesized using either a one-pot method for allylation of aldehydes or by direct allylation of the corresponding acetals using bismuth triflate as a catalyst. The remarkably low toxicity, low cost and ease of handling of bismuth salts coupled with the mild nature of the electrochemical procedure makes this approach to indane synthesis especially environmentally friendly and attractive. Georg Thieme Verlag Stuttgart.
