817160-27-3

Basic information

• Product Name: N-(2,2-dimethoxyethyl)-2,2,2-trifluoro-N-(2-hydroxybenzyl)acetamide
• Synonyms: N-(2,2-dimethoxyethyl)-2,2,2-trifluoro-N-(2-hydroxybenzyl)acetamide
• CAS NO: 817160-27-3
• Molecular Weight: 307.27
• Mol File: 817160-27-3.mol

Chemical Properties

• CAS DataBase Reference: N-(2,2-dimethoxyethyl)-2,2,2-trifluoro-N-(2-hydroxybenzyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,2-dimethoxyethyl)-2,2,2-trifluoro-N-(2-hydroxybenzyl)acetamide(817160-27-3)
• EPA Substance Registry System: N-(2,2-dimethoxyethyl)-2,2,2-trifluoro-N-(2-hydroxybenzyl)acetamide(817160-27-3)

Safety Data

• Hazardous Substances Data: 817160-27-3(Hazardous Substances Data)

Upstream product

• 89-95-2 2-methyl-benzyl alcohol 
• 183266-61-7 1-(trifluoroacetyl)benzotriazole 
• 817160-26-2 2-(2-hydroxybenzylamino)acetaldehyde dimethyl acetal 

Relevant articles and documents

Synthesis of tetrahydrobenzoxazepine acetals with electron-withdrawing groups on the nitrogen atom. Novel scaffolds endowed with anticancer activity against breast cancer cells

Synthetic approaches that have led to (RS)-3-methoxy-N-substituded-1,2,3,5- tetrahydro-4,1-benzoxazepines with different electron-withdrawing groups, and (RS)-2-methoxy-N-trifluoroacetyl-2,3,4,5-tetrahydro-1,4-benzoxazepine are described. These novel synthons that were designed to be used as scaffolds for the preparation of new O,N-acetals as anticancer agents, unexpectedly proved to show antiproliferative activity against the MCF-7 breast cancer cell line. It has been found that substituents on the nitrogen atom have an influence on biological activity. In particular, the presence of a trifluoroacetyl moiety on the nitrogen atom leads to amides displaying interesting in vitro antitumour activities. Graphical Abstract.