817176-74-2Relevant academic research and scientific papers
Synthesis and evaluation of novel α-heteroaryl-phenylpropanoic acid derivatives as PPARα/γ dual agonists
Casimiro-Garcia, Agustin,Bigge, Christopher F.,Davis, Jo Ann,Padalino, Teresa,Pulaski, James,Ohren, Jeffrey F.,McConnell, Patrick,Kane, Christopher D.,Royer, Lori J.,Stevens, Kimberly A.,Auerbach, Bruce,Collard, Wendy,McGregor, Christine,Song, Kun
experimental part, p. 7113 - 7125 (2010/03/30)
The synthesis of a new series of phenylpropanoic acid derivatives incorporating an heteroaryl group at the α-position and their evaluation for binding and activation of PPARα and PPARγ are presented in this report. Among the new compounds, (S)-3-{4-[3-(5-
Preparation of N2-alkylated 1,2,3-triazoles
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Page/Page column 18, (2010/02/10)
Methods and materials for preparing N2-alkylated triazoles, such as 3-{4-[3-(5-methyl-2-phenyl-oxazol-4-yl)-propyl]-phenyl}-2-[1,2,3]triazol-2-yl-propionic acid, are disclosed. Such compounds are PPAR agonists that are useful for treating non-insulin depe
