81718-77-6

Basic information

• Product Name: 5-METHOXY-3-METHYL-BENZOFURAN-2-CARBOXYLIC ACID
• Synonyms: 5-methoxy-3-methyl-2-Benzofurancarboxylic acid;5-methoxy-3-methyl-1-benzofuran-2-carboxylic acid
• CAS NO: 81718-77-6
• Molecular Formula: C₁₁H₁₀O₄
• Molecular Weight: 206.2
• Mol File: 81718-77-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 367.1°Cat760mmHg
• Flash Point: 175.8°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 4.91E-06mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: 5-METHOXY-3-METHYL-BENZOFURAN-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-3-METHYL-BENZOFURAN-2-CARBOXYLIC ACID(81718-77-6)
• EPA Substance Registry System: 5-METHOXY-3-METHYL-BENZOFURAN-2-CARBOXYLIC ACID(81718-77-6)

Safety Data

• Hazardous Substances Data: 81718-77-6(Hazardous Substances Data)

Usage

General Description

5-METHOXY-3-METHYL-BENZOFURAN-2-CARBOXYLIC ACID is a chemical compound that belongs to the benzofuran class of compounds. It is a derivative of benzofuran and contains a carboxylic acid group. 5-METHOXY-3-METHYL-BENZOFURAN-2-CARBOXYLIC ACID is commonly used in medical and pharmaceutical research due to its potential therapeutic properties. It has been studied for its potential use as an anti-inflammatory, antimicrobial, and anticancer agent. The presence of the methoxy and methyl groups in the compound's structure may contribute to its biological activities, making it a potential candidate for drug development.

InChI:InChI=1/C11H10O4/c1-6-8-5-7(14-2)3-4-9(8)15-10(6)11(12)13/h3-5H,1-2H3,(H,12,13)

Upstream product

• 33038-04-9 ethyl 2-(2-acetyl-4-methoxyphenoxy)acetate 
• 10242-08-7 5-methoxybenzofuran-2-carboxylic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 1275991-88-2 N-(2-fluorophenyl)-4-(5-(5-methoxy-3-methylbenzofuran-2-carboxamido)pyridin-2-yl)piperazine-1-carboxamide 

Relevant articles and documents

Benzofuran Derivatives. Part 4. Synthesis of Benzofurans and 2,3,4,5-Tetrahydro-1-benzoxepin-3,5-diones

By treatment of ethyl 4- or 5-substituted 2-acetylphenoxyacetates 1 with potassium hydroxide in dry dioxane, benzofurans 2-7 and 2,3,4,5-tetrahydro-1-benzoxepin-3,5-diones 8 were obtained.The relative yields of benzofurans 2-7 and 2,3,4,5-tetrahydro-1-benzoxepin-3,5-diones 8 varied with the types of 4- or 5-substituents.The electron-donating 4-methoxyl group favored the formation of benzoxepins.On the other hand, electron-withdrawing substituents such as the 4-nitro group favored the formation of benzofurans.When esters 1 were treated with sodium amide,2,3-dihydrobenzofurans 2 were obtained exclusively regardless of 4- or 5-substituents.

METHODS FOR THE HOMOLOGATION OF BENZOFURANCARBOXYLIC ACIDS USING DIANIONIC INTERMEDIATES

Dianions (2), (5), and (10), can be derived from the corresponding benzofurancarboxylic acids using lithium diisopropylamide, and are useful intermediates for the homologation of the parent acids.