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Usage

Uses

Used in Pharmaceutical Research:
5-METHOXY-3-METHYL-BENZOFURAN-2-CARBOXYLIC ACID is used as a potential therapeutic agent for various conditions due to its anti-inflammatory, antimicrobial, and anticancer properties. The presence of methoxy and methyl groups in its structure likely enhances these biological activities, making it a candidate for drug development.
Used in Anti-Inflammatory Applications:
In the medical field, 5-METHOXY-3-METHYL-BENZOFURAN-2-CARBOXYLIC ACID is used as an anti-inflammatory agent, helping to reduce inflammation and associated symptoms.
Used in Antimicrobial Applications:
5-METHOXY-3-METHYL-BENZOFURAN-2-CARBOXYLIC ACID is utilized as an antimicrobial agent, working to combat microbial infections and contributing to the development of new antibiotics.
Used in Anticancer Applications:
In oncology, 5-METHOXY-3-METHYL-BENZOFURAN-2-CARBOXYLIC ACID is employed as a potential anticancer agent, being studied for its ability to target and inhibit cancer cell growth and proliferation.

InChI:InChI=1/C11H10O4/c1-6-8-5-7(14-2)3-4-9(8)15-10(6)11(12)13/h3-5H,1-2H3,(H,12,13)

Upstream product

• 33038-04-9 ethyl 2-(2-acetyl-4-methoxyphenoxy)acetate 
• 10242-08-7 5-methoxybenzofuran-2-carboxylic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 1275991-88-2 N-(2-fluorophenyl)-4-(5-(5-methoxy-3-methylbenzofuran-2-carboxamido)pyridin-2-yl)piperazine-1-carboxamide 

Relevant academic research and scientific papers

Benzofuran Derivatives. Part 4. Synthesis of Benzofurans and 2,3,4,5-Tetrahydro-1-benzoxepin-3,5-diones

By treatment of ethyl 4- or 5-substituted 2-acetylphenoxyacetates 1 with potassium hydroxide in dry dioxane, benzofurans 2-7 and 2,3,4,5-tetrahydro-1-benzoxepin-3,5-diones 8 were obtained.The relative yields of benzofurans 2-7 and 2,3,4,5-tetrahydro-1-benzoxepin-3,5-diones 8 varied with the types of 4- or 5-substituents.The electron-donating 4-methoxyl group favored the formation of benzoxepins.On the other hand, electron-withdrawing substituents such as the 4-nitro group favored the formation of benzofurans.When esters 1 were treated with sodium amide,2,3-dihydrobenzofurans 2 were obtained exclusively regardless of 4- or 5-substituents.

The Generation and Synthetic Utility of Dianions derived from Benzofurancarboxylic Acids

The dianionic species, lithium 2-lithiobenzofuran-3-carboxylate (5) and lithium 3-lithiobenzofuran-2-carboxylate (11b) can be readily generated from the parent acids by reaction with lithium diisopropylamide in tetrahydrofuran at low temperatures.While co

METHODS FOR THE HOMOLOGATION OF BENZOFURANCARBOXYLIC ACIDS USING DIANIONIC INTERMEDIATES

Dianions (2), (5), and (10), can be derived from the corresponding benzofurancarboxylic acids using lithium diisopropylamide, and are useful intermediates for the homologation of the parent acids.