817617-07-5Relevant academic research and scientific papers
γ-Lactones as templates in ring-closing metathesis: Enantioselective synthesis of medium sized carbocycles fused to butyrolactones
Ravelo, José Luis,Rodríguez, Carmen Ma,Martín, Víctor S.
, p. 5326 - 5335 (2007/10/03)
A methodology for accessing enantiomerically enriched carbocyclic systems fused to γ-lactones is described. Key steps are the stereoselective synthesis of highly substituted γ-lactones and ring-closing metathesis of the suitable ramifications. The process permits the choice of stereochemistry, regioselectivity and ring size of the fused compounds.
γ-Lactone-tethered ring-closing metathesis. A route to enantiomerically enriched γ-lactones α,β-fused to medium-sized rings
Rodriguez, Carmen M.,Ravelo, Jose Luis,Martin, Victor S.
, p. 4787 - 4789 (2007/10/03)
(Chemical Equation Presented) The stereoselective alkylation of α(phenylsulfonyl)-β-[(methoxycarbonyl)methyl]-γ-lactones obtained by the base-induced cyclization of enantiomericaily enriched α-[(phenylthio)acyl]-α,β-unsaturated esters and ring-closing olefin metathesis (RCM) are the basis of a new approach for gaining access to γ-lactones that are α,β-fused to medium-sized carbocycles and cyclic ethers.
