817620-19-2Relevant academic research and scientific papers
Conformationally locked isostere of phosphoSer-cis-Pro inhibits Pin1 23-fold better than phosphoSer-trans-Pro isostere
Wang, Xiaodong J.,Xu, Bailing,Mullins, Ashley B.,Neiler, Freda K.,Etzkorn, Felicia A.
, p. 15533 - 15542 (2007/10/03)
Stereoisomeric cis and trans substrate analogues for Pin1 were designed and synthesized. The central phosphoSer-Pro core of the Pin1 substrate was replaced by cis and trans amide isosteres in Ac-Phe-Phe-pSer-Ψ[(Z and E)CH=C]-Pro-Arg-NH2, 1 and
