817621-54-8

Basic information

• Product Name: C₂₃H₂₆O₆
• Synonyms: C₂₃H₂₆O₆
• CAS NO: 817621-54-8
• Molecular Weight: 398.456
• Mol File: 817621-54-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₆O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₆O₆(817621-54-8)
• EPA Substance Registry System: C₂₃H₂₆O₆(817621-54-8)

Safety Data

• Hazardous Substances Data: 817621-54-8(Hazardous Substances Data)

Upstream product

• 91784-10-0 ethyl-(ξ-L-erythro-2-deoxy-pentofuranoside) 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 141846-57-3 3,5-di-O-(4-methylbenzoyl)-2-deoxy-α-L-erythro-pentofuranosyl chloride 

Relevant articles and documents

Synthesis of beta-L-2'-deoxy nucleosides

An improved process for the preparation of 2′-modified nucleosides and 2′-deoxy-nucleosides, such as, β-L-2′-deoxy-thymidine (LdT), is provided. In particular, the improved process is directed to the synthesis of a 2′-deoxynucleoside that may utilize different starting materials but that proceeds via a chloro-sugar intermediate or via a 2,2′-anhydro-1-furanosyl-nucleobase intermediate. Where an 2,2′-anhydro-1-furanosyl base intermediate is utilized, a reducing agent, such as Red-Al, and a sequestering agent, such as 15-crown-5 ether, that cause an intramolecular displacement reaction and formation of the desired nucleoside product in good yields are employed. An alternative process of the present invention utilizes a 2,2′-anhydro-1-furanosyl base intermediate without a sequestering agent to afford 2′-deoxynucleosides in good yields. The compounds made according to the present invention may be used as intermediates in the preparation of other nucleoside analogues, or may be used directly as antiviral and/or antineoplastic agents.