817622-77-8Relevant academic research and scientific papers
Synthesis, biophysical studies and RNA interference activity of RNA having three consecutive amide linkages
Tanui, Paul,Kennedy, Scott D.,Lunstad, Benjamin D.,Haas, Amanda,Leake, Devin,Rozners, Eriks
, p. 1207 - 1210 (2014)
RNA sequences having up to three consecutive internal amide linkages were synthesized and studied using UV and NMR spectroscopy. The amide modifications did not interfere with normal base-pairing and A-type RNA conformation. Three consecutive amides were well tolerated in the passenger strand of siRNA and caused little change in RNAi activity.
Concurrent Hydrogenation of Three Functional Groups Enables Synthesis of C3′-Homologated Nucleoside Amino Acids
Kotikam, Venubabu,Rozners, Eriks
, p. 4122 - 4125 (2017/08/14)
Internucleoside amide linkages are excellent mimics of phosphodiesters in RNA and may be used to optimize the properties of short interfering RNAs. Herein we report a remarkably straightforward, efficient and step economic synthesis of C3′-homologated uri
