817624-22-9Relevant academic research and scientific papers
An improved protocol for the SmI2-promoted C-alkylation of peptides: Degradation and functionalization of serine residues in linear and cyclic peptides
Blakskj?r, Peter,Gavrila, Adina,Andersen, Lisbeth,Skrydstrup, Troels
, p. 9091 - 9094 (2007/10/03)
The utility of the samarium diiodide promoted C-alkylation of peptides for the introduction of new side chains on peptide strands is dramatically enhanced by the initial oxidative degradation of serine residues in small peptides. In this way, cyclic pepti
CONVERSION OF SERINE AND THREONINE RESIDUES INTO α-ACYLOXY-, α-ALKYLTHIO-, AND α-HALOGENOGLYCINE MOIETIES: A NEW STRATEGY FOR THE MODIFICATION OF PEPTIDES
Apitz, Gregor,Steglich, Wolfgang
, p. 3163 - 3166 (2007/10/02)
Selective modification of serine and threonine containing peptides is accomplished by oxidation with lead tetraacetate.Conversion of the derived α-acetoxyglycine derivative into α-alkylthio- and α-halogenoglycine residues offers a novel synthetic route to
