81763-90-8

Upstream product

• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 81763-89-5 Cyclohexyl-[1-(3,4-dihydro-1H-isoquinolin-2-yl)-meth-(Z)-ylidene]-amine 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 927406-87-9 2-(4,5-dihydro-thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline 
• 81763-82-8 {2-[(E)-Cyclohexyliminomethyl]-1,2,3,4-tetrahydro-isoquinolin-1-yl}-(3,4-dimethoxy-phenyl)-methanol 

Relevant academic research and scientific papers

4,5-Dihydrothiazoline - A new protecting and activating group for generation of α-aminocarbanions of secondary amines

4,5-Dihydrothiazoline has been successfully used as a protecting and activating group for synthesis of various 1-substituted 1,2,3,4- tetrahydroisoquinolines via a lithiation-electrophillic substitution reaction sequence. Copyright Taylor & Francis Group, LLC.

DIPOLE STABILIZED α-AMINO CARBANIONS. II. ALKYLATION OF TETRAHYDROISOQUINOLINES IN THE 1-POSITION.

N-Formamidine derivatives of tetrahydroisoquinolines are metalated and alkylated to give 1-substituted derivatives.Regeneration of the parent amine is accomplished by several different reagents.