817642-33-4

Upstream product

• 201230-82-2 carbon monoxide 
• 99734-06-2 α,α-bis(4-fluorophenyl)allyl alcohol 
• 1021-25-6 1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one 
• 345-92-6 4,4'-Difluorobenzophenone 

Downstream Products

• 1841-19-6 fluspirilene 
• 1841-17-4 8-[4,4-bis(4-fluorophenyl)-but-3-enyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one 

Relevant academic research and scientific papers

Regioselective hydroaminomethylation of 1,1-diaryl-allyl-alcohols: A new access to 4,4-diarylbutylamines

Pharmacologically active 4,4-diarylbutylamines like Fluspirilene and 4-amino-1,1-diarylbutan-1-ols like Difenidol were prepared in high yields via rhodium catalysed hydroaminomethylation of 1,1-diaryl-allylalcohols. Conversion of these olefins with carbon monoxide, hydrogen and secondary amines proceeds with complete regioselectivity. This group can easily be removed under acidic and hydrogenating conditions, enabling the transformation of 4-amino-1,1-diarylbutan-1-ols to 4,4-diarylbutylamines in high yields. Thus Fluspirilene was synthesised in 88% yield in four steps starting from commercially available materials. Graphical Abstract.