81777-56-2Relevant academic research and scientific papers
Nucleic acid related compounds. 38. Smooth and high-yield iodination and chlorination at C-5 of uracil bases and p-toluyl-protected nucleosides
Robins, Morris, J.,Barr, Philip J.,Giziewicz, Jerzy
, p. 554 - 557 (2007/10/02)
Treatment of uracil bases and protected nucleosides with iodine monochloride (ICl) gave the corresponding 5-iodouracil products in over 95percent purified yields.Analogously facile chlorination was effected with iodobenzene dichloride (PhICl2).Protection of the nucleosides as p-toluyl esters provided reactants that were soluble in organic solvents and crystallized readily in high yields.
