81779-30-8Relevant academic research and scientific papers
Process for the preparation of indole derivatives
-
, (2008/06/13)
The present invention provides a process for the preparation of 4-hydroxyindole derivatives of the general formula: STR1 in which R1 is a hydrogen atom or an alkyl radical containing up to 6 carbon atoms and R2 is a hydrogen atom or an alkyl radical containing up to 6 carbon atoms, wherein a compound of the general formula: STR2 in which R2 has the same meaning as above, is reacted with a compound of the general formula: in which R1 has the same meaning as above and R3 is a reactive residue, to give a 2-(2-imino-6-oxocyclohexylidene)-propionic acid derivative of the general formula: STR3 in which R1, R2 and R3 have the same meanings as above, which is then cyclized in known manner to give a compound of the general formula: STR4 in which R1 and R2 have the same meaning as above, which is subsequently dehydrated. The present invention also provides new 4-hydroxyindoles of general formula (I'), as well as new 4-Oxo-4,5,6,7-tetrahydroindoles of general formula (IV).
