81816-05-9

Basic information

• Product Name: 8,9-dimethoxy-6,7-dihydro[1,3]dioxolo[4,5-h]indeno[2,1-a][3]benzazepin-12(5H)-one
• CAS NO: 81816-05-9
• Molecular Formula: C₂₀H₁₇NO₅
• Molecular Weight: 351.3527
• Mol File: 81816-05-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 617.2°C at 760 mmHg
• Flash Point: 327.1°C
• Density: 1.44g/cm³
• Vapor Pressure: 3.66E-15mmHg at 25°C
• Refractive Index: 1.683
• CAS DataBase Reference: 8,9-dimethoxy-6,7-dihydro[1,3]dioxolo[4,5-h]indeno[2,1-a][3]benzazepin-12(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8,9-dimethoxy-6,7-dihydro[1,3]dioxolo[4,5-h]indeno[2,1-a][3]benzazepin-12(5H)-one(81816-05-9)
• EPA Substance Registry System: 8,9-dimethoxy-6,7-dihydro[1,3]dioxolo[4,5-h]indeno[2,1-a][3]benzazepin-12(5H)-one(81816-05-9)

Safety Data

• Hazardous Substances Data: 81816-05-9(Hazardous Substances Data)

Upstream product

• 81633-53-6 rel-(8R,14R)-5,6,7,8,13,14-hexahydro-14-hydroxy-9,10-dimethoxy-2,3-methylenedioxybenzindeno<1,2-b>azepin-13-one 
• 81633-53-6 rel-(8R,14S)-5,6,7,8,13,14-hexahydro-14-hydroxy-9,10-dimethoxy-2,3-methylenedioxybenzindeno<1,2-b>azepin-13-one 
• 80665-65-2 9,10-dimethoxy-2,3-methylenedioxy-8,14-cycloberbin-13-one 
• 81633-57-0 rel-(8R,14R)-7-acetyl-5,6,7,8,13,14-hexahydro-14-hydroxy-9,10-dimethoxy-2,3-methylenedioxybenzindeno<1,2-b>azepin-13-one 

Relevant articles and documents

Chemical transformation of protoberberines. VII. Efficient conversion of protoberberines into benzindenoazepines via 8,14-cycloberbines.

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Conversion of a Protopine into an Indenobenzazepine. Stereoselective Formation of cis- and trans-B/C Fused Indenobenzazepines

Treatment of the protopine (7) with strong base and sunlight yields the cis-fused indenobenzazepine (8) while reaction of the oxo-aziridine (9) with acidic reagents leads to the trans-indenobenzazepines (13), (15), and (17), which isomerize with time in the reaction medium to the corresponding cis-analogues (14), (16), and (18).