81816-05-9

Upstream product

• 81633-57-0 rel-(8R,14R)-7-acetyl-5,6,7,8,13,14-hexahydro-14-hydroxy-9,10-dimethoxy-2,3-methylenedioxybenzindeno<1,2-b>azepin-13-one 
• 81633-53-6 rel-(8R,14R)-5,6,7,8,13,14-hexahydro-14-hydroxy-9,10-dimethoxy-2,3-methylenedioxybenzindeno<1,2-b>azepin-13-one 
• 81633-53-6 rel-(8R,14S)-5,6,7,8,13,14-hexahydro-14-hydroxy-9,10-dimethoxy-2,3-methylenedioxybenzindeno<1,2-b>azepin-13-one 
• 80665-65-2 9,10-dimethoxy-2,3-methylenedioxy-8,14-cycloberbin-13-one 

Relevant academic research and scientific papers

Conversion of a Protopine into an Indenobenzazepine. Stereoselective Formation of cis- and trans-B/C Fused Indenobenzazepines

Treatment of the protopine (7) with strong base and sunlight yields the cis-fused indenobenzazepine (8) while reaction of the oxo-aziridine (9) with acidic reagents leads to the trans-indenobenzazepines (13), (15), and (17), which isomerize with time in the reaction medium to the corresponding cis-analogues (14), (16), and (18).