81819-48-9Relevant academic research and scientific papers
Peptide-Chain Elongation Using Unprotected Amino Acids in a Micro-Flow Reactor
Fuse, Shinichiro,Masuda, Koshiro,Otake, Yuma,Nakamura, Hiroyuki
supporting information, p. 15091 - 15097 (2019/11/13)
Conventional peptide synthesis requires a deprotection step after each amidation step, which decreases synthetic efficiency. Therefore, peptide synthesis using unprotected amino acids is considered an ideal approach. Here, we report peptide chain elongati
COMPOUNDS FOR AMIDE-FORMING REACTIONS
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Page/Page column 31; 32, (2014/01/07)
Provided herein is a compound of Formula I, that displays remarkable physicochemical properties as a peptide-coupling additive for peptide-forming reactions in water, wherein said coupling reactions proceed without measurable racemization. A method of pro
Synthesis of selenoxo peptides and oligoselenoxo peptides employing LiAlHSeH
Vishwanatha,Narendra,Chattopadhyay, Basab,Mukherjee, Monika,Sureshbabu, Vommina V.
experimental part, p. 2689 - 2702 (2012/06/01)
Synthesis of selenoxo peptides by the treatment of Nα- protected peptide esters with a combination of PCl5 and LiAlHSeH is delineated. The method is simple, high-yielding, and free from racemization. Thus obtained selenoxo peptides are used as units for N-terminal chain extension through Nα-deprotection/coupling to yield peptide-selenoxo peptide hybrids. Multiple selenation is demonstrated by conversion of two peptide bonds of tripeptides into selenoxo peptide bonds. Amino acid derived arylamides are also converted into aryl selenoamides. C6H 5-CSeNH-Val-OMe 8f is obtained as single crystal, and its structure was determined through X-ray diffraction study.
A new oxyma derivative for nonracemizable amide-forming reactions in water
Wang, Qinghui,Wang, Yong,Kurosu, Michio
supporting information; experimental part, p. 3372 - 3375 (2012/09/07)
An Oxyma derivative, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-2-(hydroxyimino)acetate (2), displayed remarkable physicochemical properties as a peptide-coupling additive for peptide-forming reactions in water. Short peptides to oligopeptides could b
Microwave accelerated high speed solution synthesis of peptides employing HATU/HOAt
Sudarshan, Naremaddepalli S.,Suresh Babu, Vommina V.
, p. 1509 - 1511 (2007/10/03)
The chemical synthesis of peptides employing HATU/HOAt as a coupling agent under microwave irradiation has been described. The couplings found to be complete in 30-40 s. The yield as well as purity of the peptides made is found to be good. All the peptide
