81820-40-8Relevant academic research and scientific papers
Synthesis of some novel imidazolinones as potent anticonvulsant agents
Joshi, Hashmukh,Upadhyay, Paresh,Karia, Denish,Baxi
, p. 837 - 840 (2003)
Imidazolinone derivatives of IIa-IIc, IIIa-IIIf and IVa-IVf have been synthesised by the condensation of some known sulpha drugs with 5-oxazolone derivatives, which were prepared by Erlenmeyer condensation of benzoyl glycine with different aldehydes in th
Synthesis and in vitro carbonic anhydrases and acetylcholinesterase inhibitory activities of novel imidazolinone-based benzenesulfonamides
Tugrak, Mehtap,Gul, Halise Inci,Demir, Yeliz,Levent, Serkan,Gulcin, Ilhami
, (2020/12/09)
New imidazolinone-based benzenesulfonamides 3a–e and 4a–e were synthesized in three steps?and their chemical structures were confirmed by 1H NMR (nuclear magnetic resonance), 13C NMR, and high-resolution mass spectrometry. The benzenesulfonamides used were sulfacetamide (3a, 4a), sulfaguanidine (3b, 4b), sulfanilamide (3c, 4c), sulfadiazine (3d, 4d), sulfamerazine (3e), and sulfathiazole (4e). The compounds were evaluated against carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes to obtain possible drug candidate/s. The lead compounds of the series were 3a and 4a against human CA (hCA) I, whereas?3d and 4a were leads against hCA II in terms of Ki values. Series 4 includes more effective CAs inhibitors than series 3 (except 3d). Series 4 compounds having a nitro group (except 4d) were 3.3–4.8 times more selective inhibitors than their corresponding analogues 3a–d in series 3, in which hydrogen was located in place of the nitro group, by considering Ki values against hCA II. Compounds 3c and 4c, where the sulfanilamide moiety is available, were the leads in terms of AChE inhibition with the lowest Ki values. The use of secondary sulfonamides was a more effective modification on CA inhibition, whereas the primary sulfonamide was the effective substitution in terms of AChE inhibitory potency.
2-Phenyl-4-arylidene-2-imidazolin-5-ones and Their Derivatives
Badr, M. Z.,El-Sherief, H. A. H.,Tadros, M. E.
, p. 1093 - 1094 (2007/10/02)
A new series of esters and amides (III - VIII) of 1-(p-carboxyphenyl)-2-phenyl-4-arylidene-2-imidazolin-5-ones (IIa - c) have been obtained.Condensation of 2-phenyl-4-arylidene-2-oxazolin-5-ones (I) with sulphonamides gives the corresponding 1-(p-sulphona
