81829-18-7Relevant academic research and scientific papers
REACTION OF DERIVATIVES OF 4,7-DIBROMO-2H-BENZIMIDAZOLE N-OXIDES WITH AMINES
Samsonov, V. A.,Volodarskii, L. B.
, p. 569 - 574 (2007/10/02)
The reaction of 4,7-dibromo-2,2-dimethyl-4,5,6,7-tetrahydro-2H-benzimidazole 1,3-dioxide with amines leads to 4,7-diamino-2,2-dimethyl-4,5,6,7-tetrahydro-2H-benzimidazole 1,3-dioxides, which are converted smoothly into 4,7-diamino-2,2-dimethyl-2H-benzimidazoles by the action of silica gel or aluminum oxide.Bromination of 2,2-dimethyl-4,5,6,7-tetrahydro-2H-benzimidazole 1,3-dioxide with an excess of N-bromosuccinimide gave 4,4,7,7-tetrabromo-2,2-dimethyl-4,5,6,7-tetrahydro-2H-benzimidazole 1,3-dioxide, dehydrobromination of which gave 4,7-dibromo-2,2-dimethyl-2H-benzimidazole 1,3-dioxide and 4,7-dibromo-2,2-dimethyl-2H-benzimidazole 1-oxid e.The reaction of these compounds with morpholine led to the formation of products from addition of morpholine at position 5 of the benzimidazole, and both elimination and retention of the N-oxide groups was observed.
