818377-35-4Relevant academic research and scientific papers
Lobelane analogues as novel ligands for the vesicular monoamine transporter-2
Zheng, Guangrong,Dwoskin, Linda P.,Deaciuc, Agripina G.,Zhu, Jun,Jones, Marlon D.,Crooks, Peter A.
, p. 3899 - 3909 (2007/10/03)
A series of lobelane analogues has been synthesized and their structure-activity relationships at the vesicular monoamine transporter-2 (VMAT2) have been evaluated. The most potent analogues in this series were the cis-2,6-piperidino analogues, 25b, 27b, 28b, and 30b, with Ki values ranging from 430 to 580 nM.
