81841-12-5Relevant academic research and scientific papers
Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase
Gigante, Alba,Priego, Eva-María,Sánchez-Carrasco, Paula,Ruiz-Pérez, Luis Miguel,Vande Voorde, Johan,Camarasa, María- José,Balzarini, Jan,González-Pacanowska, Dolores,Pérez-Pérez, María-Jesús
, p. 459 - 465 (2014/07/07)
8-Arylinosines have been scarcely studied for therapeutic purposes, probably due to difficulties in their synthesis. The recently described direct arylation reaction at position 8 of purine nucleosides has been employed to synthesize a series of 8-aryl and 8-pyridylinosines. These compounds have been studied for hydrolytic stability and subjected to biological evaluation. Three compounds have shown a pronounced specific inhibition of Plasmodium falciparum-encoded purine nucleoside phosphorylase, an important target for antimalarial chemotherapy.
THE REACTIONS OF BENZENEDIAZONIUM IONS WITH SOME PURINES AND PYRIMIDINES
Hung, Ming-Hong,Stock, Leon M.
, p. 67 - 75 (2007/10/02)
The reactions of certain pyrimidines and purines with benzenediazonium ions in basic solution have been investigated to determine whether the reactions provide triazenes, azo coupling, or phenylation products.Under these conditions, the anion of uracil fo
