81860-76-6Relevant academic research and scientific papers
Direct defluorinative amidation-hydrolysis reaction of gem-difluoroalkenes with N,N-dimethylformamide, and primary and secondary amines
Wang, Biyun,Zhao, Xianghu,Liu, Qingyun,Cao, Song
, p. 8546 - 8552 (2018/12/01)
A novel and efficient method for the synthesis of arylacetamides by the reactions of gem-difluoroalkenes with N,N-dialkylformamides, and primary and secondary amines with the assistance of KOtBu and water was developed.
Visible-light-mediated eosin y catalyzed aerobic desulfurization of thioamides into amides
Yadav, Arvind K.,Srivastava, Vishnu P.,Yadav, Lal Dhar S.
, p. 4119 - 4124 (2013/12/04)
A novel method for the metal-free efficient synthesis of amides from thioamides using visible light and in an air atmosphere in the presence of eosin Y as an organophotoredox catalyst is reported. The protocol involves aerobic desulfurization-oxygenation of thioamides into amides in good to excellent yields at r.t. in a one-pot operation under mild conditions with the formation of nontoxic elemental sulfur as the only by-product. On the basis of several relevant experiments performed, it has been shown that the present photooxidation does not involve a singlet oxygen and accordingly a plausible organocatalytic photoredox mechanism is proposed.
Direct use of dioxygen as an oxygen source: Catalytic oxidative synthesis of amides
Wei, Wei,Hu, Xiao-Yu,Yan, Xiao-Wei,Zhang, Qiang,Cheng, Ming,Ji, Jian-Xin
supporting information; experimental part, p. 305 - 307 (2012/01/06)
The first transition-metal-catalyzed direct oxidative synthesis of amides by using dioxygen as an oxygen source has been developed under mild conditions, in which DBU was used as the key additive. The present methodology, which utilizes dioxygen as an oxidant and oxygen source and cheap copper salts as catalysts, opens up an interesting and attractive avenue for the synthesis of amide functionality.
Cesium carbonate promoted aerobic oxidation of arylacetamides: an efficient access to N-substituted α-keto amides
Song, Bingrui,Wang, Siyuan,Sun, Caiyun,Deng, Hongmei,Xu, Bin
, p. 8982 - 8986 (2008/03/18)
A novel cesium carbonate promoted aerobic oxidation reaction to prepare N-substituted α-keto amides in the presence of catalytic amount of tetra-n-butylammonium bromide was described. This reaction provides a very simple and convenient route from easily a
A facile one-carbon homologation of aryl aldehydes to amides.
Shen, Wang,Kunzer, Aaron
, p. 1315 - 1317 (2007/10/03)
The easily accessible 2-aryl-1,1-dibromo-1-alkenes can be converted to amides under unusually mild conditions in good to excellent yields. Both electron-donating and electron-withdrawing substitutions on the aromatic rings are tolerated, and the reaction works well with hindered alkylamines. This simple homologation could find broad applications. [reaction: see text]
Oxidation of Thioamides with Ceric Ammonium Nitrate: Transformation of Thiocarbonyl to Corresponding Oxygen Analogue
Dhar, Durga Nath,Bag, Amal Kumar
, p. 445 - 446 (2007/10/02)
Primary thioamide, viz. thiobenzamide (3) on oxidation with ceric ammonium nitrate gives 3,5-diphenyl-1,2,4-thiadiazole.Secondary and tertiary thioamides on similar oxidation yield the corresponding amides.
Electro-organic Reactions. Part 22. An Entry into the Quinolizidine and Benzoquinolizidine Ring Systems via Anodic Methoxylation
Palasz, Peter D.,Utley, James H. P.,Hardstone, J. David
, p. 281 - 292 (2007/10/02)
Examples of the quinolizidine and benzoquinolizidine ring systems (1,1-bisethoxycarbonyl-4-oxo-quinolizidine, 1,3,4,6,7,11b-hexahydro-2H-benzoquinolizidine, and 1,2-t-butyl-3,4,6,7,11b-hexahydro-2H-benzo-quinolizidine) have been synthesized by routes which involve initial anodic methoxylation of piperidine precursors with subsequent intramolecular Lewis acid-catalysed cyclisation reactions.Reaction conditions for such cyclisations have been explored; success depends on a correct choice of catalyst (usually aluminium chloride) and, critically, on steric factors.The stereochemistry of the cyclic products has been established and the stereochemical course of the reactions is commented upon.
Ringopening of 3-Substituted 2,3-Epoxynitriles under Acetylating Conditions
Althoff, Wolfgang,Tinapp, Peter
, p. 289 - 294 (2007/10/02)
The reactivity of 2,3-epoxynitriles 1 towards various acetylating agents was studied.Depending on the reaction conditions, 2,3-diacetoxynitriles 2, 2-acetoxy-3-chloronitriles 5 or enol acetates of α-ketonitriles 3 are formed as main products.
