81866-98-0Relevant academic research and scientific papers
A new series of cyclic amino acids as inhibitors of S-adenosyl L- methionine synthetase
Lavrador, Karine,Guillerm, Danielle,Guillerm, Georges
, p. 1629 - 1634 (2007/10/03)
Optically active 3-amino-3-(tetrahydrofuranyl) carboxylic acid, 3- amino-3-(tetrahydrothienyl) carboxylic acid and their corresponding six membered ring analogues have been synthesised and examined as potential inhibitors of the enzyme S-adenosylmethionine (AdoMet) synthetase. The kinetic behaviour of these compounds was studied using recombinant rat liver AdoMet synthetase (α-isoform) fractionated from E. coli transformed with the plasmid pSSRL-T7N. All the compounds tested were competitive inhibitors of the enzyme with respect to L-methionine.
Inhibiting growth hormone secretion with 5,5-substituted hydantoin derivatives
-
, (2008/06/13)
The compounds are free hydantoin derivatives of the formula: STR1 wherein X is a divalent radical consisting of from 2 to 5 linked units; one unit being --O--, and from one to 4 hydrocarbon units, independently, having the structure in which R is alkyl having from 1 to 6 carbon atoms and being free of branching on the α-carbon atoms; provided that no more than 2 units are of type b; or a pharmaceutically acceptable salt form thereof with a suitable cation; e.g. 7-oxa-1,3-diazaspiro[4.4]nonane-2,4-dione, and are useful as pharmaceuticals.
