81870-99-7Relevant academic research and scientific papers
6-Quinazolinesulfonyl derivatives and process for preparation thereof
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, (2008/06/13)
A 6-quinazolinesulfonyl derivative of Formula (I): STR1 wherein R1 is a hydrogen atom or a C1-12 alkyl group: R2 is a hydrogen atom, a C1-12 alkyl group, a C4-10 cycloalkyl group, an aryl group or an aralkyl group; and R1 and R2 may be linked directly or through an oxygen atom to form a 5- to 7-membered heterocyclic ring together with the adjacent nitrogen atom; and R3 is a STR2 group wherein R4 is a C1-8 alkyl group; a --HN(CH2)n NH2 group wherein n is an integer of 2 to 10; or a STR3 group; and the pharmaceutically acceptable salt thereof; and a process for the preparation thereof. The compounds of this invention have a relaxatory action for vascular smooth muscle and are useful as a vasodilator and a hypotensor.
