81873-08-7

Basic information

• Product Name: Forskolin J
• Synonyms: Forskolin J
• CAS NO: 81873-08-7
• Molecular Formula: C₂₄H₃₆O₈
• Molecular Weight: 452.53784
• Mol File: 81873-08-7.mol

Chemical Properties

• Melting Point: 265-267 °C(Solv: chloroform (67-66-3); ethyl acetate (141-78-6))
• Boiling Point: 530.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.22±0.1 g/cm3(Predicted)
• PKA: 10.83±0.70(Predicted)
• CAS DataBase Reference: Forskolin J(CAS DataBase Reference)
• NIST Chemistry Reference: Forskolin J(81873-08-7)
• EPA Substance Registry System: Forskolin J(81873-08-7)

Safety Data

• Hazardous Substances Data: 81873-08-7(Hazardous Substances Data)

Usage

Uses

Used in Cardiovascular Applications:
Forskolin J is used as a therapeutic agent for cardiovascular conditions, leveraging its capacity to enhance cAMP levels, which can improve heart function and blood vessel dilation, thereby promoting better blood flow and reducing blood pressure.
Used in Respiratory Applications:
In respiratory disorders, Forskolin J is utilized as a treatment to alleviate symptoms and improve lung function, capitalizing on its potential to relax smooth muscles and reduce inflammation in the airways.
Used in Dermatological Applications:
Forskolin J is applied in skin condition treatments, serving as an anti-inflammatory and anti-microbial agent, which can help soothe skin irritations, promote healing, and combat certain skin infections.
Used in Anti-Inflammatory and Anti-Cancer Applications:
Forskolin J is employed as an anti-inflammatory and anti-cancer agent, due to its ability to modulate immune responses and inhibit the growth of cancer cells, making it a potential asset in cancer therapy and inflammatory condition management.
Used in Weight Loss Supplements:
As a weight loss supplement, Forskolin J is used to increase the breakdown of fats in the body, which can aid in weight management and support overall health by promoting a more efficient metabolism.

Synthetic route

acetic anhydride (108-24-7) + (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6-(acetyloxy)-3-ethenyldodecahydro-5,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one (64657-21-2) → 6-O-acetylforskolin (81873-08-7)

Conditions	Yield
With pyridine 1.) 0-5 deg C, 3 h, 2.) room temperature, 0.5 h;	0.078 g

forskolin (66575-29-9) → 6-O-acetylforskolin (81873-08-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: 0.55 g / basic alumina / benzene / 120 h 2: 0.078 g / pyridine / 1.) 0-5 deg C, 3 h, 2.) room temperature, 0.5 h View Scheme

6-O-acetylforskolin (81873-08-7) → C24H34O8

Conditions	Yield
With Collins oxidation agent In dichloromethane at 20℃; for 2.5h;	2.5 mg

6-O-acetylforskolin (81873-08-7) → 8,13-epoxy-6β,7β,9α-trihydroxylabd-14-ene-1,11-dione

Conditions	Yield
Multi-step reaction with 2 steps 1: 2.5 mg / Collins reagent / CH2Cl2 / 2.5 h / 20 °C 2: 1.9 mg / K2CO3 / methanol / 3 h / 20 °C View Scheme

Upstream product

• 66575-29-9 forskolin 
• 108-24-7 acetic anhydride 
• 64657-21-2 (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6-(acetyloxy)-3-ethenyldodecahydro-5,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one 

Relevant articles and documents

Reactions of Forskolin, a Biologically Active Diterpenoid from Coleus forskohlii

Forskolin (1) (7β-acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one), the major diterpenoid of Coleus forskohlii, has potent positive inotropic, antihypertensive, and adenylate cyclase stimulant properties.The reactivity of its various functional groups (1α-OH, 6β-OH, the derived 7β-OH, 9α-OH, 11-oxo, and 14,15-double bond) has been studied through acylation, alkylation, dehydration, oxidation, and reduction reactions.