81873-08-7

Basic information

• Product Name: Forskolin J
• Synonyms: Forskolin J
• CAS NO: 81873-08-7
• Molecular Formula: C₂₄H₃₆O₈
• Molecular Weight: 452.53784
• Mol File: 81873-08-7.mol

Chemical Properties

• Melting Point: 265-267 °C(Solv: chloroform (67-66-3); ethyl acetate (141-78-6))
• Boiling Point: 530.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.22±0.1 g/cm3(Predicted)
• PKA: 10.83±0.70(Predicted)
• CAS DataBase Reference: Forskolin J(CAS DataBase Reference)
• NIST Chemistry Reference: Forskolin J(81873-08-7)
• EPA Substance Registry System: Forskolin J(81873-08-7)

Safety Data

• Hazardous Substances Data: 81873-08-7(Hazardous Substances Data)

Usage

General Description

Forskolin J is a chemical compound found in the roots of the Indian Coleus plant (Plectranthus barbatus). It is a natural diterpene that has been found to have various pharmacological properties, including the ability to increase levels of cyclic adenosine monophosphate (cAMP) in cells, which can lead to a wide range of physiological effects. Forskolin J has been studied for its potential use in treating cardiovascular conditions, respiratory disorders, and skin conditions, as well as for its potential anti-inflammatory and anti-cancer properties. Additionally, it has been researched for its potential as a weight loss supplement due to its ability to increase the breakdown of fats in the body. Overall, Forskolin J shows promise as a therapeutic agent with a diverse range of potential applications.

Synthetic route

acetic anhydride (108-24-7) + (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6-(acetyloxy)-3-ethenyldodecahydro-5,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one (64657-21-2) → 6-O-acetylforskolin (81873-08-7)

Conditions	Yield
With pyridine 1.) 0-5 deg C, 3 h, 2.) room temperature, 0.5 h;	0.078 g

forskolin (66575-29-9) → 6-O-acetylforskolin (81873-08-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: 0.55 g / basic alumina / benzene / 120 h 2: 0.078 g / pyridine / 1.) 0-5 deg C, 3 h, 2.) room temperature, 0.5 h View Scheme

6-O-acetylforskolin (81873-08-7) → C24H34O8

Conditions	Yield
With Collins oxidation agent In dichloromethane at 20℃; for 2.5h;	2.5 mg

6-O-acetylforskolin (81873-08-7) → 8,13-epoxy-6β,7β,9α-trihydroxylabd-14-ene-1,11-dione

Conditions	Yield
Multi-step reaction with 2 steps 1: 2.5 mg / Collins reagent / CH2Cl2 / 2.5 h / 20 °C 2: 1.9 mg / K2CO3 / methanol / 3 h / 20 °C View Scheme