81875-28-7

Upstream product

• 81875-24-3 2-(3-Oxo-2-phenylsulfanyl-cyclopentyl)-propionic acid ethyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 5296-64-0 allyl phenyl thioether 
• 81875-34-5 2-(2-Methyl-3-oxo-cyclopentyl)-propionic acid ethyl ester 
• 81875-30-1 2-((1S,2S)-2-Allyl-2-methyl-3-oxo-cyclopentyl)-propionic acid ethyl ester 
• 81875-35-6 2-(2,4-Diallyl-2-methyl-3-oxo-cyclopentyl)-propionic acid ethyl ester 

Relevant academic research and scientific papers

Michael Reactions in Aprotic Media. An Effective Method of Construction of α,α,β-Trisubstituted Ketones and Application to Natural Product Synthesis

By proper selection of the reaction conditions, 1,4-additions of malonate and propionate anions to 2-(phenylthio)-2-cyclopentenone were accomplished.Subsequent trapping of the intermediate enolates with an electrophile in the aprotic media afforded α,α,β-trisubstituted ketones regiospecifically.The effects of the counterion, solvent, and temperature were examined.An application of this method to the formal synthesis of the pseudoguaianolides (+/-)-aromatin and (+/-)-confertin is described.