81877-79-4

Upstream product

• 81877-77-2 3-Jod-7-methyl-4'-methoxy-flavanon 
• 75328-80-2 1-(2-Hydroxy-4-methyl-phenyl)-3-(4-methoxy-phenyl)-propane-1,3-dione 
• 107095-26-1 3-(2-hydroxy-5-methylphenyl)-5-(4-methoxyphenyl)pyrazoline 
• 81819-87-6 1-<2-Hydroxy-4-methyl-phenyl>-3-<4-methoxy-phenyl>-prop-2-en-1-on 
• 80649-82-7 4-Methoxy-benzoic acid 2-acetyl-5-methyl-phenyl ester 

Relevant academic research and scientific papers

PIRAZOLE MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

The present invention relates to pyrazoles of formula (I) which are modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator ("CFTR"), compositions thereof, and methods therewith. The

Oxidation of Pyrazolines with Manganese Dioxide

Pyrazolines have been oxidised with manganese dioxide in chloroform at room temperature to give pyrazoles in good yields.

Reaction of 3-Iodoflavanones with Hydrazine Hydrate & Phenylhydrazine: Synthesis of Pyrazoles

3-Iodoflavanones (IIa-d), obtained from 2'-hydroxy-4-methoxychalkones and ICl in acetic acid, when reacted with N2H4 * H2O in ethanol at room temperature give 3,5-diarylpyrazoles (IIIa-d) while with C6H5NH-NH2 * HCl in pyridine, 3,5-diaryl-1-phenylpyrazoles (IVa-d) are obtained.The identity of III and IV has been confirmed by independent and unambiguous synthesis of these pyrazoles from 2-hydroxydibenzoylmethanes.