81887-01-6 Usage
Uses
Used in Pharmaceutical Industry:
4-Methyl-6-hydroxy-5-(2-propynyl)-2-pyrimidinamine is used as a potential therapeutic agent for the treatment of neurological disorders. Its unique structure and properties have been studied for their potential to alleviate symptoms and slow the progression of diseases such as Parkinson's and Alzheimer's.
Used in Research and Development:
This pyrimidinamine analogue is used in scientific research to explore its potential as a novel therapeutic agent. Further studies are being conducted to understand its mechanism of action, efficacy, and safety profile in treating neurological disorders, with the aim of advancing its development for clinical use.
Check Digit Verification of cas no
The CAS Registry Mumber 81887-01-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,8,8 and 7 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 81887-01:
(7*8)+(6*1)+(5*8)+(4*8)+(3*7)+(2*0)+(1*1)=156
156 % 10 = 6
So 81887-01-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H9N3O/c1-3-4-6-5(2)10-8(9)11-7(6)12/h1H,4H2,2H3,(H3,9,10,11,12)
81887-01-6Relevant academic research and scientific papers
Reynolds, Robert C.,Trask, Todd W.,Sedwick, W. David
, p. 2391 - 2395 (1991)
The synthesis of 2,4-dichloro-5-(1-o-carboranylmethyl)-6-methylpyrimidine is described.Synthetically, this novel o-carboranyl pyrimidine is approached from ethyl 2-acetyl-4-pentynoate through alkylation of ethyl acetoacetate with propargyl bromide and subsequent condensation with thiourea to yield 6-methyl-5-(2-propynyl)-2-thio-4(1H,3H)-pyrimidinone.Hydrolysis of the 2-thione and chlorination wirh POCl3 gives 2,4-dichloro-6-methyl-5-(2-propynyl)pyrimidine.Gentle refluxing of this product with B10H14/CH3CN in toluene yields the target, 2,4-dichloro-5-(1-o-carboranylmethyl)-6-methylpyrimidine, a potential synthon for a variety of 2,4-substituted 5-(1-o-carboranylmethyl)-6-methylpyrimidines and/or the corresponding nido-undecaborates.
