81902-49-0

Upstream product

• 83304-61-4 diethyl(N-benzyl)-N-(2,4-dimethoxy-benzyl)-amino-malonate 
• 13433-00-6 diethyl aminomalonate hydrochloride 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 83304-60-3 benzyl (2,4-dimethoxybenzyl)-amine 
• 96724-73-1 N-benzyl-1-(2,4-dimethoxyphenyl)methanamine 

Downstream Products

• 107731-69-1 2-[(2-Bromo-propionyl)-(2,4-dimethoxy-benzyl)-amino]-malonic acid diethyl ester 
• 102357-51-7 2-[(2-Bromo-butyryl)-(2,4-dimethoxy-benzyl)-amino]-malonic acid diethyl ester 
• 94271-65-5 diethyl (+/-)-N-(2-bromo-3-methylbutanoyl)-N-(2,4-dimethoxybenzyl)aminomalonate 
• 86694-73-7 Diethyl 1-(2,4-dimethoxybenzyl)-4-oxo-2,2-azetidine-dicarboxylate 
• 1236764-76-3 diethyl 3-amino-1-(2,4-dimethoxybenzyl)-5-oxo-1,5-dihydro-2H-pyrrol-2,2-dicarboxylate 
• 86694-72-6 diethyl N-(2,4-dimethoxy-benzyl)-N-(chloroacetyl)-amino-malonate 
• 91922-04-2 diethyl (+/-)-3-ethyl-1-(2,4-dimethoxybenzyl)-4-oxo-2,2-azetidinedicarboxylate 
• 81902-64-9 <3S-<3α(S^*),4β>>-1-(2,4-dimethoxybenzyl)-3-(1-t-butyldimethylsilyloxyethyl)-4-diazoacetyl-2-azetidinone 
• 81902-67-2 [(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-acetic acid methyl ester 
• 81902-65-0 <3S-<3α(S^*),4β>>-benzyl<1-(2,4-dimethoxybenzyl)-3-(1-t-butyldimethylsilyloxyethyl)-2-azetidinone-4-yl>acetate 
• 85621-92-7 Ethyl (2RS,3SR)-1-(2,4-Dimethoxybenzyl)-3-(2-methyl-1,3-dioxolan-2-yl)-4-oxoazetidine-2-carboxylate 
• 85621-92-7 trans ethyl 1-(2,4-dimethoxybenzyl)-3-(2-methyl-1,3-dioxolan-2-yl)-4-oxoazetidinecarboxylate 
• 87542-16-3 (2RS,3RS)-1-(2,4-dimethoxybenzyl)-3-(2-methyl-1,3-dioxolan-2-yl)-4-oxoazetidine-2-carboxylic acid 
• 87231-35-4 [(2S,3R)-1-(2,4-Dimethoxy-benzyl)-3-(2-methyl-[1,3]dioxolan-2-yl)-4-oxo-azetidin-2-yl]-acetonitrile 

Relevant academic research and scientific papers

Azetidinone acetic acid derivatives and process for the preparation thereof

The invention relates to compounds of the general formula (X) STR1 wherein R is as a removable protecting substituent of the amido group a phenyl group or a benzyl group substituted by one or more alkoxy group(s) having 1-4 carbon atoms and R1 stands for a hydrogen atom or an alkyl group having 1-4 carbon atoms and a process for the preparation thereof. The compounds of the general formula (X) can be prepared from the starting materials of the general formula (V), wherein R and R1 are as stated above and Z is an alkyl group having 1-4 carbon atoms. The compounds of the general formula (X) are useful pharmaceutical intermediates which can be used in the preparation of known antibiotics (e.g. Thienamycin and PS-5).

SIMPLE AND CONDENSED β-LACTAMS-I. THE APPLICATION OF DIKETENE IN β-LACTAM SYNTHESIS. THE SYNTHESIS AND FUNCTIONAL GROUP MANIPULATIONS OF DIETHYL 3-ACETYL-4-OXOAZETIDINE-2,2-DICARBOXYLATES

Acetylation of the N-substituted diethyl aminomalonates 3a-3d with diketene furnished the ring tautomers 6a-6d of the expected acetoacetyl derivatives 5.By treatment with iodine and sodium ethoxide compounds 6a-6d are smoothly converted into the β-lactam

Azetidinone-4-carboxylate containing a protected 3-acetyl group and process for their preparation

The invention relates to new heterocyclic compounds containing a protected C-acetyl group. More particularly, the invention concerns new compounds of the Formula (V) STR1 wherein R is a group suitable for the protection of amides; Z is alkyl; and Y1

Beta-lactam compounds containing a protected C-acetyl group, process for their preparation and pharmaceutical compositions containing them

The invention relates to new heterocyclic compounds containing a protected C-acetyl group. More particulary, the invention concerns new compounds of the formula (VI) STR1 wherein R1 is hydrogen or a group suitable for a temporary protection or amides, X is hydroxyl, halogen, cyano or an --O--SO2 --R2 group, in which R2 is lower alkyl or aryl, Y1 and Y2 together form a group suitable for a temporary protection of a keto group. The new compounds possess anaphylactic properties and are valuable intermediates of thienamycin synthesis. Their preparation and the new intermediates obtained during their preparation are also within the scope of the invention.

Heterocyclic compounds containing an alkoxycarbonyl and a substituted methyl group

The invention relates to new heterocyclic compound containing an alkoxycarbonyl and a substituted methyl group a process for the preparation of these and analogeous compound and pharmaceutical compositions containing them. More particularly, the invention concerns compounds of the general formula (IVa) STR1 wherein R' is hydrogen, 2-ethoxycarbonylethyl, aryl or a group suitable for a temporary protection of amides and Y' represents a group of the formula --COOZ or --CH2 M, in which Z is lower alkyl and M is hydroxyl, halogen, cyano or a group of the formula --O--SO2 R2, in which R2 is lower alkyl or aryl, with the proviso that if R' is phenyl, Y' cannot stand for the group --COOC2 H5. The invention further relates to a process for the preparation of compounds of the general formula (IV) STR2 in which R and Y are identical with R' and Y', respectively, except the proviso. According to a further aspect of the invention there are provided pharmaceutical compositions, first of all with antihypoxic activity, comprising compounds of the general formula (IVa) as active ingredient.