81903-80-2

Basic information

• Product Name: 3,4-DIBROMOBENZENESULFONYL CHLORIDE
• Synonyms: 3,4-DIBROMOBENZENESULFONYL CHLORIDE
• CAS NO: 81903-80-2
• Molecular Formula: C₆H₃Br₂ClO₂S
• Molecular Weight: 334.41
• Mol File: 81903-80-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 34 °C
• Boiling Point: 346.9 °C at 760 mmHg
• Flash Point: 163.6 °C
• Appearance: /
• Density: 2.11 g/cm³
• Vapor Pressure: 0.000112mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 3,4-DIBROMOBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIBROMOBENZENESULFONYL CHLORIDE(81903-80-2)
• EPA Substance Registry System: 3,4-DIBROMOBENZENESULFONYL CHLORIDE(81903-80-2)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3261
• HazardClass: MOISTURE SENSITIVE, CORROSIVE
• Hazardous Substances Data: 81903-80-2(Hazardous Substances Data)

Usage

General Description

3,4-Dibromobenzenesulfonyl chloride is a chemical compound that is derived from benzene. It is a yellow solid that is soluble in organic solvents and reacts violently with water. 3,4-DIBROMOBENZENESULFONYL CHLORIDE is commonly used as a reagent in organic synthesis to introduce the sulfonamide functional group into various organic molecules. It is also used in the pharmaceutical industry to synthesize sulfonamide-based drugs. Additionally, it is used in the production of dyes, pigments, and various other fine chemicals. 3,4-DIBROMOBENZENESULFONYL CHLORIDE is considered to be a hazardous material and should be handled with caution due to its corrosive and toxic properties.

InChI:InChI=1/C6H3Br2ClO2S/c7-5-2-1-4(3-6(5)8)12(9,10)11/h1-3H

Upstream product

• 7790-94-5 chlorosulfonic acid 
• 7664-93-9 sulfuric acid 
• 583-53-9 2,3-dibromobenzene 

Downstream Products

• 81902-95-6 4-N,N-diethylsulfamoyl-1,2-dibromobenzene 
• 224824-31-1 1-(3,4-dibromophenylsulfonyl)indole 
• 224824-27-5 1-(3,4-dibromophenylsulfonyl)pyrrole 
• 107573-20-6 1,2-dibromobenzene-4-sulfonic acid 
• 224824-33-3 1-(3,4-dicyanophenylsulfonyl)pyrrole 
• 224824-34-4 1-(3,4-dicyanophenylsulfonyl)indole 
• 224824-32-2 3,4-dicyano-N,N-diphenylbenzenesulfonamide 
• 345892-69-5 3,4-Dibromo-N-[4-chloro-3-(2-dimethylamino-ethoxy)-phenyl]-benzenesulfonamide 
• 81903-11-9 4-(N,N-dibutylsulfamoyl)-1,2-dicyanobenzene 
• 81903-12-0 3,4-Dicyano-N-cyclohexyl-benzenesulfonamide 

Relevant articles and documents

A convenient one-pot synthesis of boroxoles from diboronic acid

The preparation of the boroxole motif traditionally relies on a 3-step process and the use of n-butyl lithium that can limit substrate scope. Herein during our exploration toward novel RORγ inhibitors, we identified a convenient one-pot preparation of the motif in good yields with good substrate scope.

Synthesis and radiopharmacological characterisation of a fluorine-18-labelled azadipeptide nitrile as a potential PET tracer for invivo imaging of cysteine cathepsins

A fluorinated cathepsin inhibitor based on the azadipeptide nitrile chemotype was prepared and selected for positron emission tomography (PET) tracer development owing to its high affinity for the oncologically relevant cathepsins L, S, K and B. Labelling with fluorine-18 was accomplished in an efficient and reliable two-step, one-pot radiosynthesis by using 2-[18F]fluoroethylnosylate as a prosthetic agent. The pharmacokinetic properties of the resulting radiotracer compound were studied invitro, exvivo and invivo in normal rats by radiometabolite analysis and small-animal positron emission tomography. These investigations revealed rapid conjugate formation of the tracer with glutathione in the blood, which is associated with slow blood clearance. The potential of the developed 18F-labelled probe to image tumour-associated cathepsin activity was investigated by dynamic small-animal PET imaging in nude mice bearing tumours derived from the human NCI-H292 lung carcinoma cell line. Computational analysis of the obtained image data indicated the time-dependent accumulation of the radiotracer in the tumours. The expression of the target enzymes in the tumours was confirmed by immunohistochemistry with specific antibodies. This indicates that azadipeptide nitriles have the potential to target thiol-dependent cathepsins invivo despite their disadvantageous pharmacokinetics.

PHTHALOCYANINES AND ALLIED COMPOUNDS. ALKYLAMIDES OF ISOMERIC PHTHALOCYANINE-TETRASULFONIC AND -OCTASULFONIC ACIDS

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