819053-59-3Relevant academic research and scientific papers
COMPOUNDS AND USES FOR THE TREATMENT AND PREVENTION OF DISEASES AND CONDITIONS ASSOCIATE WITH OR AGGRAVATED BY IMPARED MITOPHAGY
-
Paragraph 00101-00103, (2019/10/04)
The present invention provides compounds and methods for the treatment and prevention of diseases and conditions associate with or aggravated by impaired mitophagy.
The Delicate Balance of Preorganisation and Adaptability in Multiply Bonded Host–Guest Complexes
von Krbek, Larissa K. S.,Achazi, Andreas J.,Schoder, Stefan,Gaedke, Marius,Biberger, Tobias,Paulus, Beate,Schalley, Christoph A.
supporting information, p. 2877 - 2883 (2017/03/08)
Rigidity and preorganisation are believed to be required for high affinity in multiply bonded supramolecular complexes as they help reduce the entropic penalty of the binding event. This comes at the price that such rigid complexes are sensitive to small geometric mismatches. In marked contrast, nature uses more flexible building blocks. Thus, one might consider putting the rigidity/high-affinity notion to the test. Multivalent crown/ammonium complexes are ideal for this purpose as the monovalent interaction is well understood. A series of divalent complexes with different spacer lengths and rigidities has thus been analysed to correlate chelate cooperativities and spacer properties. Too long spacers reduce chelate cooperativity compared to exactly matching ones. However, in contrast to expectation, flexible guests bind with chelate cooperativities clearly exceeding those of rigid structures. Flexible spacers adapt to small geometric host–guest mismatches. Spacer–spacer interactions help overcome the entropic penalty of conformational fixation during binding and a delicate balance of preorganisation and adaptability is at play in multivalent complexes.
Conventional tetrakis(triphenylphosphine)palladium-copper(I) iodide-catalyzed sonogashira coupling of free and BOC-Protected propargylic amines "On water"
Soberats, Bartomeu,Martinez, Luis,Vega, Manuel,Rotger, Carmen,Costa, Antoni
supporting information; experimental part, p. 1727 - 1731 (2011/02/26)
Alkynylation of aryl iodides with propargylic amines has been achieved by means of a Sonogashira coupling using "on water" methods. The use of less than 0.2mol% of tetrakis(triphenylphosphine)palladium [Pd(PPh 3)4] and 1.5 mol% coppe
Inhibition of Streptococcus suis adhesion by dendritic galabiose compounds at low nanomolar concentration
Joosten, John A. F.,Loimaranta, Vuokko,Appeldoorn, Chantal C. M.,Haataja, Sauli,El Maate, Fatna Ait,Liskamp, Rob M. J.,Finne, Jukka,Pieters, Roland J.
, p. 6499 - 6508 (2007/10/03)
A series of mono-, di-, and tetravalent galabiose (Galα1-4Gal) compounds were synthesized in good yields by coupling of a general carboxylic acid-bearing sugar building block to dendritic scaffolds based on the 3,5-di-(2-aminoethoxy)benzoic acid branching
