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4-(4-Aminophenyl)-1H-indazol-3-amine, also known as AG1478, is a chemical compound that serves as a potent inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It is characterized by its ability to selectively target and block the activation of EGFR, which plays a crucial role in cell growth and proliferation. AG1478 has been extensively studied for its potential as a therapeutic agent in the treatment of various types of cancer and as a valuable research tool for understanding the complex signaling pathways associated with EGFR.

819058-89-4

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819058-89-4 Usage

Uses

Used in Pharmaceutical Industry:
4-(4-Aminophenyl)-1H-indazol-3-amine is used as an anti-cancer agent for its potential to inhibit the growth of tumor cells in various types of cancer. Its mechanism of action involves blocking the activation of EGFR, thereby disrupting the signaling pathways that promote cell proliferation and tumor growth.
Used in Scientific Research:
4-(4-Aminophenyl)-1H-indazol-3-amine is used as a research tool for studying the role of EGFR in various physiological processes and diseases. Its selective inhibition of EGFR makes it valuable in elucidating the complex signaling pathways involved in cell growth, proliferation, and the development of cancer.
Used in Drug Development:
4-(4-Aminophenyl)-1H-indazol-3-amine is being investigated as a potential therapeutic agent for the treatment of cancer. Its promising results in preclinical studies have led to further exploration of its efficacy and safety in clinical trials, with the aim of developing new targeted cancer therapies.
Used in Drug Delivery Systems:
Although not explicitly mentioned in the provided materials, AG1478 could potentially be incorporated into drug delivery systems to improve its bioavailability, targeting, and therapeutic outcomes. This would involve the development of novel formulations or carriers that facilitate the efficient delivery of AG1478 to cancer cells while minimizing side effects on healthy tissues.

Check Digit Verification of cas no

The CAS Registry Mumber 819058-89-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,1,9,0,5 and 8 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 819058-89:
(8*8)+(7*1)+(6*9)+(5*0)+(4*5)+(3*8)+(2*8)+(1*9)=194
194 % 10 = 4
So 819058-89-4 is a valid CAS Registry Number.

819058-89-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(4-Aminophenyl)-1H-indazol-3-amine

1.2 Other means of identification

Product number -
Other names QC-1103

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:819058-89-4 SDS

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