819075-46-2Relevant academic research and scientific papers
Structure-activity relationships in platelet-activating factor. 12. Synthesis and biological evaluation of platelet-activating factor antagonists with anti-HIV-1 activity
Serradji, Nawal,Martin, Marc,Bensaid, Okkacha,Cisternino, Salvatore,Rousselle, Christophe,Dereuddre-Bosquet, Nathalie,Huet, Jack,Redeuilh, Catherine,Lamouri, Aazdine,Dong, Chang-Zhi,Clayette, Pascal,Scherrmann, Jean-Michel,Dormont, Dominique,Heymans, Fran?oise
, p. 6410 - 6419 (2007/10/03)
The HIV-1 central nervous system infection leads to the onset of neurological impairments called AIDS dementia complex (ADC). PAF plays an important role in this pathology, as it is an HIV-1-induced neurotoxin produced by infected or activated macrophages
