819079-58-8

Basic information

• Product Name: 1H-Indole-3-acetamide, N-(4-aminobutyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
• CAS NO: 819079-58-8
• Molecular Formula: C23H26ClN3O3
• Molecular Weight: 427.931
• Mol File: 819079-58-8.mol

Chemical Properties

• CAS DataBase Reference: 1H-Indole-3-acetamide, N-(4-aminobutyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-acetamide, N-(4-aminobutyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-(819079-58-8)
• EPA Substance Registry System: 1H-Indole-3-acetamide, N-(4-aminobutyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-(819079-58-8)

Safety Data

• Hazardous Substances Data: 819079-58-8(Hazardous Substances Data)

Upstream product

• 960215-53-6 N-(4-aminobutyl)-2-{1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl}acetamide hydrochloride 
• 960215-52-5 tert-butyl (4-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamido}butyl)carbamate 
• 53-86-1 [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid 

Relevant articles and documents

CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING

Conjugates derived from non-steroidal anti-inflammatory drugs (NSAIDs) and methods of use thereof are disclosed, useful for, inter alia, identifying and localizing the site of pathology and/or inflammation responsible for the sensation of pain in a patient; for identifying the sites of primary, secondary, benign, or malignant tumors; and for diagnosing infection or confirming or ruling out suspected infection. The NSAID-based conjugates contain an imaging moiety. The conjugates concentrate at sites of increased cyclooxygenase expression, thus revealing the sites of increased prostaglandin production, which is correlated with pain and inflammation, and correlated with tumor presence and/or location. Identifying areas of increased COX expressing can also aid in screening for infections.

Methods and compositions for diagnostic and therapeutic targeting of COX-2

The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell and/or treating a disorder associated with a cyclooxygenase-2 biological activity.

COX-2-targeted imaging agents

The presently disclosed subject matter provides a method for synthesizing a radiological imaging agent by reacting a COX-2-selective ligand with a compound comprising a detectable group, wherein the COX-2-selective ligand is a derivative of a non-steroidal anti-inflammatory drug (NSAID) comprising an ester moiety or a secondary amide moiety. Also provided are compositions that are synthesized using the method, as well as methods of using the compositions of the presently disclosed subject matter.