81928-62-3Relevant academic research and scientific papers
Synthesis of substituted N-formylaminomethylenediphosphonates and their derivatives
Prishchenko, Andrey A.,Livantsov, Mikhail V.,Novikova, Olga P.,Livantsova, Ludmila I.,Averochkin, Gleb M.,Petrosyan, Valery S.
, p. 405 - 410 (2015)
The convenient methods for the synthesis of new trimethylsilyl esters of aminomethylenediphosphonic acids are elaborated. The new substituted N-formylaminomethylenediphosphonates are obtained via the interaction of trimethylsilyl esters of methylenediphosphonic acids with a mixture of triethyl orthoformate and ethanol. Also boron trifluoride-diethyl etherate as an effective catalyst is used for the interaction of hydrochlorides of ethoxymethylene imines with diethyl trimethylsilyl phosphite. The corresponding aminomethylenediphosphonic acids are presented.
ZnCl2-Mediated Double Addition of Dialkylphosphite to Nitriles for the Synthesis of 1-Aminobisphosphonates
Kaboudin, Babak,Esfandiari, Hesam,Moradi, Atieh,Kazemi, Foad,Aoyama, Hiroshi
, p. 14943 - 14948 (2019/11/11)
In this study, the double addition of dialkylphosphite to nitriles in a ZnCl2/Et3N system is described. The reaction was conveniently and directly used for the synthesis of biologically important 1-aminobisphosphonates (ABPs) from ni
Synthesis of (aminomethylene)bisphosphonic acid derivatives
Prishchenko,Livantsov,Novikova,Livantsova,Petrosyan
, p. 228 - 232 (2016/11/06)
Amino derivatives of methylenebisphosphonic acids were synthesized by phosphorylation of formamide, nitriles or hydrochlorides of alkyl imidates with H3PO3—PCl3—(Me3Si)2NH.
