81950-00-7

Upstream product

• 81950-14-3 [6-(4-Chloro-phenyl)-3-phenyl-imidazo[2,1-b]thiazol-2-yl]-acetic acid ethyl ester 
• 81950-41-6 ethyl (2-amino-4-phenyl-5-thiazolyl)acetate 
• 39225-30-4 ethyl 3-benzoyl-3-bromopropionate 

Relevant academic research and scientific papers

Synthesis and Anthiinflammatory Activity of Some Arylimidazothiazolyl- and Arylimidazobenzothiazolyl-acetic Acids

Three series of the title compounds, imidazothiazolyl-, imidazobenzothiazolyl- and imidazobenzothiazolylaryl-acetic acids (II,III and IV) have been synthesised for evaluation as potential anti-inflammatory agents.Compounds II have been synthesised by condensing ethyl (2-amino-4-aryl-5-thiazolyl)acetate (VI) with phenacyl bromides followed by hydrolysis of the resultant esters (VII).III are obtained by the condensatiion of ethyl 2-aminobenzothiazole-6-acetate with phenacyl bromides followed by hydrolysis of the resultant esters (IX).Compound IV result from the treatment of 2-aminobenzothiazoles with ethyl 4(ω-bromoacetylphenyl)acetate (XI) followed by hydrolysis of the esters (XII).Some of the title compounds show good antiinflammatory activity.