81950-27-8

Upstream product

• 81950-32-5 [2-(4-Nitro-phenyl)-benzo[d]imidazo[2,1-b]thiazol-7-yl]-acetic acid ethyl ester 
• 950769-80-9 methyl[2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazol-7-yl]acetate 
• 68195-02-8 2-Amino-6-ethoxycarbonylmethylbenzothiazole 
• 99-81-0 4-Nitrophenacyl bromide 

Downstream Products

• 950770-50-0 1-morpholin-4-yl-2-[2-(4-nitro-phenyl)-imidazo[2,1-b][1,3]benzothiazol-7-yl]-ethanone 

Relevant academic research and scientific papers

Imidazolothiazole compounds for the treatment of disease

Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.

Synthesis and Anthiinflammatory Activity of Some Arylimidazothiazolyl- and Arylimidazobenzothiazolyl-acetic Acids

Three series of the title compounds, imidazothiazolyl-, imidazobenzothiazolyl- and imidazobenzothiazolylaryl-acetic acids (II,III and IV) have been synthesised for evaluation as potential anti-inflammatory agents.Compounds II have been synthesised by condensing ethyl (2-amino-4-aryl-5-thiazolyl)acetate (VI) with phenacyl bromides followed by hydrolysis of the resultant esters (VII).III are obtained by the condensatiion of ethyl 2-aminobenzothiazole-6-acetate with phenacyl bromides followed by hydrolysis of the resultant esters (IX).Compound IV result from the treatment of 2-aminobenzothiazoles with ethyl 4(ω-bromoacetylphenyl)acetate (XI) followed by hydrolysis of the esters (XII).Some of the title compounds show good antiinflammatory activity.