81963-68-0Relevant academic research and scientific papers
The preparation of 4,5-dihydro-3-aryl-naphth-[1,2-c]-isoxazoles from dilithiated 1-tetralone oxime and aromatic esters
Beam, Charles F.,Schady, Deborah A.,Rose, Kelly L.,Kelley Jr., Wayne,Rakkhit, Ronjay,Hornsby, Christopher D.,Studer-Martinez, Shannon L.
, p. 3391 - 3404 (2007/10/03)
Dilithiated 1-tetralone oxime was prepared in excess lithium diisopropylamide and condensed with a variety of esters followed by acid cyclization of C-acylated intermediates to substituted 4,5-dihydronaphth-[ 1,2-c]-isoxazoles.
The Preparation of 5-Phenacylisoxazoles and 5-Hydroxyphenylisoxazoles and -pyrazoles by the Condensation of C(α)-Dianions with Ethyl Benzoylacetate and Methyl Salicylate
Livingston, Melanie J.,Chick, MarLisa F.,Shealy, Ernest O.,Beam, Charles F.
, p. 215 - 217 (2007/10/02)
C(α),O-Dilithiooximes and C(α),N-Dilithiophenylhydrazones were prepared in an excess of lithium diisopropylamide (LDA).The former was condensed with ethyl benzoylacetate and methyl salicylate, and the latter condensed with methyl salicylate.The resulting precyclization intermediates were than treated with aqueous acid, which was followed by cyclodehydration to give phenacylisoxazoles and hydroxyphenylisoxazoles and -pyrazoles.
