819792-96-6

Upstream product

• 124-04-9 Adipic acid 
• 2216-51-5 (-)-menthol 

Downstream Products

• 1227206-02-1 N-Boc-N'-(5-(menthoxycarbonyl)pentanoyl)hydrazine 

Relevant academic research and scientific papers

The effect of the position of chiral (?)-menthyl on the formation of blue phase and mesophase behavior in biphenyl-benzoate liquid crystals

Eight new chiral liquid crystal compounds 4-(4-menthyloxy-n-oxoalkanoyloxy) biphenyl-4′-yl 4-butoxybenzoates MnB4OB (n = 1–8), were prepared by modifying the position of chiral (?)-menthyl in the menthol based liquid crystal compounds through gradually increasing the alkyl chain length of the dicarboxylic spacer. All compounds were characterized by FT-IR and NMR spectroscopy in order to prove their chemical structures. Differential scanning calorimetry (DSC), polarized optical microscopy (POM) and X-ray diffraction were carried out to systematically investigate their phase transition behaviors. The position of chiral (?)-menthyl in relation to the core has a great effect on the formation of BPs and mesomorphic behaviors. Only CLCs M1B4OB and M2B4OB with short spacer chains presented blue phases. Furthermore, the length and parity of the flexible spacers have a profound influence on phase structures and phase transition behaviors. An odd-even effect is observed for these chiral liquid crystal compounds.

DIESTER COMPOUND AS PERFUME PRECURSOR

PROBLEM TO BE SOLVED: To provide a new diester compound usable as a perfume precursor. SOLUTION: There are provided: a diester compound which has a cyclohexanol or a derivative thereof, an aroma compound having a hydroxy group, and a diester bond connecting these two compounds in a molecule, and is usable as a perfume precursor; a perfume composition containing the same; and a consumption article containing the diester compound or the perfume composition. There is also provided a method for imparting or enhancing residual perfume of the consumption article, which comprises formulating the diester compound or the perfume composition into the consumption article. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones

Doxorubicin N-acylhydrazones derived from saturated, unsaturated and terpene-terminated fatty acids were tested for anticancer activity in cells of human HL-60 leukaemia, 518A2 melanoma, MCF-7/Topo breast and KB-V1/Vbl cervix carcinomas. In the latter, the N-heptadecanoyl hydrazone was more cytotoxic than its unsaturated C18-fatty acyl analogues and even three times more than doxorubicin. The (menthoxycarbonyl)undecanoyl hydrazone was twice as active as doxorubicin in these multidrug resistant KB-V1/Vbl and in the 518A2 cells and also more efficacious in KB-V1 and MCF-7 cells that had been desensitised for doxorubicin. All hydrazones induced apoptosis albeit by slightly different mechanisms. While apoptosis induction by the menthoxymalonyl hydrazone was characterized by an upfront increase in caspase-8 activity, all other hydrazones elicited a hike in caspase-9 activity. Treatment of HL-60 and 518A2 cells with doxorubicin or its heptadecanoyl, linolenoyl, (menthoxycarbonyl)undecanoyl or menthoxymalonyl hydrazones also led to diverging increases of the ratio of bax to bcl-2 mRNA expression, of reactive oxygen species and of mitochondrial membrane damage.