819798-35-1

Upstream product

• 819798-33-9 phenyl 2-O-benzyl-3,4-O-benzylidene-1-thio-β-L-fucopyranoside 
• 848416-62-6 phenyl 2,4-di-O-benzyl-3-O-(2-naphthyl)methyl-1-thio-β-L-fucopyranoside 

Relevant academic research and scientific papers

Synthesis of the trisaccharide repeating unit of capsular polysaccharide from Klebsiella pneumoniae

The incidences of primary, pyrogenic liver abscess complicated by meningitis and septic endophthalmitis caused by Klebsiella pneumoniae has increased globally. Earlier studies have shown that the capsular polysaccharide (CPS) of Klebsiella pneumoniae plays an important role in the resistance to phagocytosis and related pathogenicity. The first chemical synthesis of the trisaccharide repeating unit of this CPS has been achieved via stereoselective glycosylation with orthogonal and appropriate protecting groups. A new method for the pyruvylation of trans diol was developed.

METHOD OF SYNTHESIZING SUGAR CHAIN

An object of the present invention is to provide a method for efficiently chemically synthesizing biomolecules including a nucleotide (nucleic acid), a peptide (protein), or a sugar chain, as representative examples. The present invention provides a metho