81980-07-6

Upstream product

• 50-00-0 formaldehyd 
• 591-49-1 1-methylcyclohex-1-ene 
• 75-24-1 trimethylaluminum 
• 99440-28-5 (6,6-dimethyl-1-cyclohexen-1-yl)methanol 
• 408318-16-1 ethyl 6,6-dimethylcyclohex-1-enecarboxylate 
• 2979-10-4 ethyl 2,2-dimethyl-6-oxocyclohexane-1-carboxylate 
• 1257045-68-3 ethyl {6,6-dimethyl-2-(trifluoromethanesulfonyloxy)cyclohexene-1-yl}carboxylate 
• 39778-69-3 1-methyl-cis-bicyclo<4.2.0>octan-7-one 

Downstream Products

• 1416557-25-9 (2,2-dimethylcyclohexyl)(4-fluorophenyl)methanone 
• 1416557-26-0 (R)-((R)-2,2-dimethylcyclohexyl)(4-fluorophenyl)methanol 
• 1441168-83-7 N-((2,2-dimethylcyclohexyl)methyl)-3-fluoroaniline 
• 1441167-97-0 N-((2,2-dimethylcyclohexyl)methyl)-3-fluoroaniline hydrochloride 
• 1441168-85-9 N-((2,2-dimethylcyclohexyl)methyl)-3-fluoro-N-methylaniline 
• 1441167-99-2 N-((2,2-dimethylcyclohexyl)methyl)-3-fluoro-N-methylaniline hydrochloride 

Relevant academic research and scientific papers

OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE

Compounds and compositions are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

Breaking of the C-C bond of cyclobutanones by rhodium(I) and its extension to catalytic synthetic reactions

A study of rhodium(I)-catalyzed synthetic transformations involving selective breaking of the C-C bond α to the carbonyl group of cyclobutanones is described. Decarbonylation took place on treatment of a cyclobutanone with an equimolar amount of (Ph3

Reactions of the Formaldehyde-Trimethylaluminum Complex with Alkenes

Reaction of CH2O*Me3Al with electron-rich alkenes gives a zwitterion that reacts further to give homoallylic alcohols (ene adducts), allylic alcohols, and the product of cis addition of a hydroxymethyl and a methyl group to the double bond.The stereochemistry and effect of alkene structure on the nature of the reaction are examined.