81995-28-0

Usage

Uses

Used in Pharmaceutical and Drug Development Industry:
AKOS B014089 is used as a building block for the synthesis of bioactive compounds due to its unique chemical structure and potential biological activities. Its distinct aromatic and heterocyclic nature may contribute to the development of new pharmaceutical agents.
Used in Analytical Chemistry:
AKOS B014089 is used as a reference standard to ensure the accuracy and reliability of analytical methods. Its distinct chemical properties make it suitable for use as a benchmark in various analytical techniques.

InChI:InChI=1/C12H16O2/c1-10(2)7-8-14-12-6-4-3-5-11(12)9-13/h3-6,9-10H,7-8H2,1-2H3

Upstream product

• 90-02-8 salicylaldehyde 
• 107-82-4 i-pentyl bromide 
• 541-28-6 isopentyl iodide 

Relevant academic research and scientific papers

Pyridopyril compound and medical application thereof

The invention relates to a pyridine ring compound and a medical application thereof as shown in a formula (I). The invention further relates to a preparation method of the compound. Use of a pharmaceutical composition and as FGFR4 inhibitor for the treatment of cancer.

Natural α-methylenelactam analogues: Design, synthesis and evaluation of α-alkenyl-γ and δ-lactams as potential antifungal agents against Colletotrichum orbiculare

In our continued efforts to improve the potential utility of the α-methylene-γ-lactone scaffold, 62 new and 59 known natural α-methylenelactam analogues including α-methylene-γ-lactams, α-arylidene-γ and δ-lactams, and 3-arylideneindolin-2-ones were synthesized as the bioisosteric analogues of the α-methylenelactone scaffold. The results of antifungal and cytotoxic activity indicated that among these derivatives compound (E)-1-(2, 6-dichlorobenzyl)-3-(2-fluorobenzylidene) pyrrolidin-2-one (Py51) possessed good selectivity with the highest antifungal activity against Colletotrichum orbiculare with IC50?=?10.4?μM but less cytotoxic activity with IC50?=?141.2?μM (against HepG2 cell line) and 161.2?μM (against human hepatic L02?cell line). Ultrastructural change studies performed by transmission electron microscope showed that Py51 could cause important cell morphological changes in C.?orbiculare, such as plasma membrane detached from cell wall, cell wall thickening, mitochondria disruption, a dramatic increase in vacuolation, and eventually a complete loss in the integrity of organelles. Significantly, mitochondria appeared one of the primary targets, as confirmed by their remarkably aberrant morphological changes. Analysis of structure–activity relationships revealed that incorporation of the aryl group into the α-exo-methylene and the N-benzyl substitution increased the activity. Meanwhile, the α-arylidene-γ-lactams have superiority in selectivity over the 3-arylideneindolin-2-ones. Based on the results, the N-benzyl substituted α-(2-fluorophenyl)-γ-lactam was identified as the most promising natural-based scaffold for further discovering and developing improved crop-protection agents.