81995-32-6

Usage

Uses

Used in Chemical Synthesis Industry:
AKOS B014087 is used as an intermediate for the synthesis of other organic compounds, contributing to the creation of a wide range of chemical products.
Used in Laboratory Research:
AKOS B014087 is used as a reagent in chemical reactions, facilitating various experimental procedures and scientific investigations in research settings.

InChI:InChI=1/C11H14O2/c1-9(2)8-13-11-6-4-3-5-10(11)7-12/h3-7,9H,8H2,1-2H3

Upstream product

• 513-38-2 Isobutyl iodide 
• 90-02-8 salicylaldehyde 
• 563-47-3 3-Chloro-2-methylpropene 
• 78-77-3 Isobutyl bromide 

Downstream Products

• 1517-59-5 (R)-o-methylbenzhydrol 
• 1517-59-5 2-methyl-(S)-benzhydrol 
• 1179356-18-3 3-[2-(2-methylpropoxy)benzyl]-9-(pyridin-4-ylcarbonyl)-3,9-diazaspiro[5.5]undecane trifluoroacetate 
• 21315-20-8 2-isobutoxyphenol 
• 467252-18-2 3-(3-isobutoxy-2-methylphenyl)propanoic acid 
• 944419-74-3 (E)-benzyl 3-(3-butoxy-2-((dimethylamino)methyl)phenyl)acrylate 
• 944419-51-6 (2-isobutoxyphenyl)N,N-dimethylmethanamine 

Relevant academic research and scientific papers

Pyridopyril compound and medical application thereof

The invention relates to a pyridine ring compound and a medical application thereof as shown in a formula (I). The invention further relates to a preparation method of the compound. Use of a pharmaceutical composition and as FGFR4 inhibitor for the treatment of cancer.

Chiral Lithium Amido Aryl Zincates: Simple and Efficient Chemo- and Enantio-Selective Aryl Transfer Reagents

An enantioselective aryl transfer is promoted using chiral tricoordinated lithium amido aryl zincates that are easily accessible reagents and whose chiral appendage is simply recovered for reuse. The arylation reaction is run in good yields (60 % average on twenty substrates) and high enantiomeric excesses (95 % ee average). This occurs whatever the ortho, meta, or para substituent borne by the substrate and a complete chemoselectivity is observed with respect to the aldehyde function. Sensitive groups such as nitriles, esters, ketones, and enolisable substrates resist to the action of the ate reagent, warranting a large scope to this methodology.

Chiral Lithium Amido Zincates for Enantioselective 1,2-Additions: Auto-assembling Reagents Involving a Fully Recyclable Ligand

A methodology consisting in carrying out enantioselective nucleophilic 1,2-additions (ee values up to 97 %) from cheap, easily accessible, and never described before, chiral lithium amido zincates is presented. These multicomponent reactants auto-assemble when mixing, in a 1:1 ratio, a homoleptic diorganozinc (R2Zn) with a chiral lithium amide (CLA). The latter, obtained after a single reductive amination, plays the role of the chiral inductor and is fully recoverable thanks to a simple acid–base wash, allowing being recycled and re-use without loss of stereochemical information.

Regulating the piezofluorochromism of 9,10-bis(butoxystyryl)anthracenes by isomerization of butyl groups

Isomers of 9,10-bis(butoxystyryl)anthracene (DSA4), including n-butyl, i-butyl and t-butyl at ortho or para positions, were designed and synthesized. All of them display an aggregation-induced emission phenomenon. Remarkably, it was found that isomerization of butyl endgroups presents significant influences on their piezofluorochromic properties. Thus, an alternative approach to design and obtain piezofluorochromic compounds is proposed here.

Probing solvent effects on mixed aggregates associating a chiral lithium amide and n-BuLi by NMR: From structure to reactivity

An NMR study of a 1 : 1 mixture of a chiral lithium amide (4a) and n-BuLi shows that depending on the solvent employed (Et2O or THF) a mixed aggregate can form in proportions that are directly related to the ees measured during the enantioselec

A green procedure for the oxidation of benzyl halides to aromatic aldehydes or ketones in aqueous media

Green oxidation of benzyl halides to the corresponding aldehydes or ketones was achieved in aqueous media using trimethylamine N-oxide generated in situ from trimethylamine and H2O2. The yield of the reaction was excellent and the workup was simple. Copyright

NOVEL BENSOPHENONE DERIVATIVES OR SALTS THEREOF

A benzophenone derivative represented by the following formula: whereinR1 represents, for example, an optionally substituted heterocyclic group, or a substituted phenyl group; Z represents, for example, an alkylene group; R2 represents, for example, a carboxyl group optionally protected with alkyl;R3 represents, for example, an optionally protected hydroxyl group; R4 represents, for example, an optionally substituted cycloalkyloxy group; and R5 represents, for example, a hydrogen atom, ???or a salt thereof has anti-arthritic activity, inhibits bone destruction caused by arthritis, and provides high safety and excellent pharmacokinetics and thus is useful as therapeutic agent for arthritis. These compounds have inhibitory effect on AP-1 activity and are useful as preventive or therapeutic agent for diseases in which excessive expression of AP-1 is involved.

The Dual Roles of Oxodiperoxovanadate Both as a Nucleophile and an Oxidant in the Green Oxidation of Benzyl Alcohols or Benzyl Halides to Aldehydes and Ketones

One catalyst, two roles: VO(O2)2- reacts as a nucleophilic oxidant under acidic conditions towards benzyl alcohols. Altogether 15 alcohols have been oxidized, in the absence of organic solvent, in excellent yields. Benzyl halides are also oxidized by H2O 2 in water catalyzed by oxodiperoxovanadate and a phase transfer catalyst into aromatic aldehydes and ketones (see scheme). This reaction is the first green oxidation of benzyl halides.

NOVEL COMPOUNDS AND MEDICINAL USE THEREOF

A compound comprising the atom corresponding to N3 and the two or more atoms selected from N1, N2, N4 and N5, said atoms constitute the pharmacophore represented by the following formula: wherein Nsu

Photocyclization Reactions. Part 1. Synthesis of Dihydrobenzofuranols Using Photocyclization of 2-Alkoxybenzaldehydes, 2'-Alkoxyacetophenones, 2-Formylphenoxyacetic Acids and 2-Acetylphenoxyacetic Acids

Photocyclization reactions were carried out on 2-alkoxybenzaldehydes 1a-f, 2'-alkoxyacetophenones 2a-h, 2-formylphenoxyacetic acids 1i-l and 2-acetylphenoxyacetic acids 2i-m.Irradiation opf 1a-f and 2a-h in acetonitrile gave the corresponding dihydrobenzofuranols 3, 5 and dihydroisobenzofuranols 4, 6.Using carboxylic acids 1i-l, 2i-m as starting materials, decarboxylation occurred immediately to give the corresponding ethers 1a-d, 2a-e.Further irradiation of the solution afforded dihydrobenzofuranols 3,5 and dihydroisobenzofuranols 4, 6.Substituent effects on photocyclization and reaction pathways are discussed.