82007-05-4

Basic information

• Product Name: FMOC-LEU-GLY-OH
• Synonyms: FMOC-LEU-GLY-OH;(9H-Fluoren-9-yl)MethOxy]Carbonyl Leu-Gly-OH
• CAS NO: 82007-05-4
• Molecular Formula: C23H26N2O5
• Molecular Weight: 410.46
• Mol File: 82007-05-4.mol

Chemical Properties

• Melting Point: 149-150 °C
• Boiling Point: 682.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.237±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 3.39±0.10(Predicted)
• CAS DataBase Reference: FMOC-LEU-GLY-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-LEU-GLY-OH(82007-05-4)
• EPA Substance Registry System: FMOC-LEU-GLY-OH(82007-05-4)

Safety Data

• Hazardous Substances Data: 82007-05-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
FMOC-LEU-GLY-OH is used as a building block for the synthesis of peptide-based drugs. Its unique composition of amino acids and the FMOC protecting group allows for the development of novel therapeutic agents with specific biological activities.
Used in Research and Development:
FMOC-LEU-GLY-OH is utilized in research settings for the study of peptide synthesis, protein structure, and function. Its presence in various peptide sequences enables researchers to investigate the role of specific amino acids in biological processes and the development of new therapeutic strategies.
Used in Peptide Synthesis:
FMOC-LEU-GLY-OH is used as a protected amino acid in the synthesis of peptides. The FMOC group protects the amine group from unwanted side reactions, allowing for the controlled and efficient assembly of peptide chains. This is particularly important in the development of complex peptide-based drugs and biological agents.
Used in Protein Synthesis and Muscle Growth:
Leucine, one of the amino acids in FMOC-LEU-GLY-OH, is an essential component of protein synthesis and plays a significant role in muscle growth and repair. Its presence in the compound contributes to the development of therapeutic agents targeting muscle health and recovery.
Used in Collagen Production and Tissue Support:
Glycine, another amino acid in FMOC-LEU-GLY-OH, is crucial for the production of collagen, a protein that supports skin, bone, and connective tissue. FMOC-LEU-GLY-OH's role in collagen synthesis makes it a valuable component in the development of treatments for various skin and tissue-related conditions.

Upstream product

• 686-50-0 L-leucyl-glycine 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 1359870-26-0 Fmoc-Leu-COSH 
• 103321-59-1 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucine, acid chloride 
• 35661-60-0 Fmoc-Leu-OH 
• 1316293-41-0 Fmoc-Leu-Gly-OMe 

Relevant articles and documents

Solid-phase peptide synthesis and solid-phase fragment coupling mediated by isonitriles

The synthesis of polypeptides on solid phase via mediation by isonitriles is described. The acyl donor is a thioacid, which presumably reacts with the isonitrile to generate a thio-formimidate carboxylate mixed anhydride intermediate. Applications of this

Characterization of Nα-Fmoc-protected dipeptide isomers by electrospray ionization tandem mass spectrometry (ESI-MSn): Effect of protecting group on fragmentation of dipeptides

A series of positional isomeric pairs of Fmoc-protected dipeptides, Fmoc-Gly-Xxx-OY/Fmoc-Xxx-Gly-OY (Xxx = Ala, Val, Leu, Phe) and Fmoc-Ala-Xxx-OY/Fmoc-Xxx-Ala-OY (Xxx = Leu, Phe) (Fmoc = [(9-fluorenylmethyl) oxy]carbonyl) and Y = CH3/H), have been characterized and differentiated by both positive and negative ion electrospray ionization ion-trap tandem mass spectrometry (ESI-IT-MSn). In contrast to the behavior of reported unprotected dipeptide isomers which mainly produce y 1+ and/or a1+ ions, the protonated Fmoc-Xxx-Gly-OY, Fmoc-Ala-Xxx-OY and Fmoc-Xxx-Ala-OY yield significant b 1+ ions. These ions are formed, presumably with stable protonated aziridinone structures. However, the peptides with Gly- at the N-terminus do not form b1+ ions. The [M + H]+ ions of all the peptides undergo a McLafferty-type rearrangement followed by loss of CO2 to form [M + H-Fmoc + H]+. The MS3 collision-induced dissociation (CID) of these ions helps distinguish the pairs of isomeric dipeptides studied in this work. Further, negative ion MS 3 CID has also been found to be useful for differentiating these isomeric peptide acids. The MS3 of [M-H-Fmoc + H]- of isomeric peptide acids produce c1-, z1 - and y1- ions. Thus the present study of Fmoc-protected peptides provides additional information on mass spectral characterization of the dipeptides and distinguishes the positional isomers. Copyright

'Glycylcyclines'. 3. 9-Aminodoxycyclinecarboxamides

A series of 9-(acylamino)doxycycline derivatives has been prepared. These analogs exhibit good activity against both tetracycline sensitive and tetracycline resistant Gram-positive (Staphylococcus aureus) and Gram- negative (Escherichia coli) bacteria tha