82009-39-0

Upstream product

• 76602-58-9 (2S,5R,6S)-6-((R)-1-Hydroxy-ethyl)-3,3-dimethyl-4,7-dioxo-4λ⁴-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid methyl ester 
• 4457-32-3 4-nitrobenzyl chloroformate 
• 69126-86-9 (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid methyl ester-4-oxide 

Downstream Products

• 82009-44-7 2-{(2R,3S)-2-((E)-3-Acetoxy-1-acetoxymethyl-propenylsulfanyl)-3-[(R)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-3-methyl-but-2-enoic acid methyl ester 
• 81976-48-9 {(2R,3S)-2-(2-Acetoxy-acetylsulfanyl)-3-[(R)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 2-oxo-propyl ester 
• 82009-45-8 Acetic acid (2R,3S)-3-[(R)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-2-ylsulfanylcarbonylmethyl ester 
• 81976-49-0 (5R,6S)-3-Acetoxymethyl-6-[(R)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 2-oxo-propyl ester 

Relevant academic research and scientific papers

SYNTHESIS OF OPTICALLY ACTIVE 6-HYDROXYETHYL PENEMS

The synthesis of optically active 6-hydroxyethyl penems introducing the side chain by an aldol condensation on methyl penicillanate S-oxide is described.