820208-98-8

Upstream product

• 88-99-3 benzene-1,2-dicarboxylic acid 

Downstream Products

• 130562-16-2 (αS,1'S)-N-(1-Phenylethyl)-2-fluoro-α-methylphenylmethylamine 
• 68285-25-6 (S)-1-(2-fluorophenyl)ethylamine 
• 1332827-96-9 (S)-2,2,2-trifluoro-N-(1-(2-(fluoro)phenyl)ethyl)acetamide 

Relevant academic research and scientific papers

Step-efficient access to chiral primary amines

Routes to enantioenriched amines are outlined that employ reductive amination and carbanion addition methods. The strategies require either one or two reaction steps from prochiral carbonyl compounds for the synthesis of the corresponding chiral primary amines. Georg Thieme Verlag Stuttgart New York.

Sequential reductive amination-hydrogenolysis: A one-pot synthesis of challenging chiral primary amines

Difficult-to-access chiral primary amines were formed in good to high yield and ee using a rare example of a one-pot synthesis from prochiral ketones (sequential reductive amination-hydrogenloysis). As a highlight we also demonstrate a one-pot reductive amination-hydrogenolysis-reductive amination (five reactions) of ortho-methoxyacetophenone resulting in the chiral diamine 1-(2-methoxyphenyl)ethyl-(2-pyridylmethyl)-amine (4) (58% overall yield, >99% ee), a new organocatalyst for aqueous enantioselective aldol reactions. Copyright