820210-76-2Relevant academic research and scientific papers
Synthesis of 4-alkynylpyrrolo[2,3-d]pyrimidines by palladium-catalyzed cross-coupling reactions
Tumkevicius, Sigitas,Masevicius, Viktoras
, p. 3815 - 3820 (2008/09/17)
The palladium-catalyzed cross-coupling reaction of methyl 5-amino-4-chloro- and 5-amino-4-iodo-7-methyl-2-(methyl-sulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6- carboxylate with various terminal alkynes has been investigated. The 4-iodo derivative was found to be a good substrate for the synthesis of various 4-alkynylpyrrolopyrimidines. A simple synthesis of 4-(indol-2-yl)pyrrolo[2,3-d] pyrimidines by the reaction of 4-iodopyrrolopyrimidine with 2-ethynyl-N- mesylaniline in the presence dichlorobis(triphenylphosphine)palladium and copper(I) iodide is described. Georg Thieme Verlag Stuttgart.
Palladium-catalysed coupling of 4-halopyrrolo[2,3-d]pyrimidines with arylacetylenes: Synthesis of a new heterocyclic system - 4H-pyrrolo[2,3,4-de] pyrimido[5′,4′:5,6][1,3]diazepino[1,7-a]indole
Tumkevicius, Sigitas,Masevicius, Viktoras
, p. 2327 - 2330 (2007/10/03)
Palladium-catalysed reaction of methyl 5-amino-4-chloro(or iodo)-7-methyl-2-methylthiopyrrolo[2,3-d]pyrimidine-6-carboxylate with arylacetylenes affords the corresponding 4-(arylethynyl)pyrrolopyrimidines. Reaction of 5-amino-4-iodopyrrolopyrimidine with
