820214-30-0Relevant articles and documents
Non-peptide calcitonin gene-related peptide receptor antagonists from a benzodiazepinone lead
Williams, Theresa M.,Stump, Craig A.,Nguyen, Diem N.,Quigley, Amy G.,Bell, Ian M.,Gallicchio, Steven N.,Zartman, C. Blair,Wan, Bang-Lin,Penna, Kimberly Della,Kunapuli, Priya,Kane, Stefanie A.,Koblan, Ken S.,Mosser, Scott D.,Rutledge, Ruth Z.,Salvatore, Christopher,Fay, John F.,Vacca, Joseph P.,Graham, Samuel L.
, p. 2595 - 2598 (2006)
High-throughput screening of the Merck sample collection identified benzodiazepinone tetralin-spirohydantoin 1 as a CGRP receptor antagonist with micromolar activity. Comparing the structure of 1 with those of earlier peptide-based antagonists such as BIB