820215-80-3

Upstream product

• 820215-73-4 (3R,4R,5S)-3-(6-chloropyridin-3-yl)-5-methoxy-4-nitrocyclohexanone 
• 159153-42-1 2-chloro-5-trans-(β-nitrovinyl)pyridine 
• 875553-02-9 allyl (4E)-2-[(1R)-1-(6-chloropyridin-3-yl)-2-nitroethyl]-5-methoxy-3-oxo-4-pentenoate 
• 875553-03-0 (4S,5R,6S)-6-(6-chloropyridin-3-yl)-2-hydroxy-4-methoxy-5-nitrocyclohex-1-enecarboxylic acid allyl ester 
• 820215-72-3 5-methoxy-3-oxo-4-pentenoic acid allyl ester 
• 820215-78-9 (1S,3R,4R,5S)-3-(6-chloropyridin-3-yl)-5-methoxy-4-nitrocyclohexanol 

Downstream Products

• 820215-82-5 methanesulfonic acid (1R,3R,4R)-3-(6-chloropyridin-3-yl)-4-nitrocyclohexyl ester 
• 140111-52-0 epibatidine 
• 152378-30-8 (-)-epibatidine 
• 875553-06-3 (1R,3R,4S)-3-(6-chloropyridin-3-yl)-4-nitro-cyclohexanol 
• 820215-74-5 (1R,3R,4R)-3-(6-chloropyridin-3-yl)-4-nitro-cyclohexanol 

Relevant academic research and scientific papers

The amino thiourea-catalyzed asymmetric nucleophilic reactions

Bifunctional amino thiourea-catalyzed asymmetric additions of several nucleophiles into electron-deficient unsaturated compounds such as nitroolefins, α,β-unsaturated imides, imines, and azodicarboxylates are described. We discovered that bifunctional thi

Enantioselective tandem Michael reaction to nitroalkene catalyzed by bifunctional thiourea: Total synthesis of (-)-epibatidine

Successive treatment of γ,δ-unsaturated β-ketoesters and nitroalkenes with a bifunctional thiourea and TMG promoted the tandem Michael addition, giving rise to highly functionalized cyclohexanones in good yields. The three contiguous stereogenic centers o

Bifunctional thiourea-catalyzed enantioselective double Michael reaction of γ,δ-unsaturated β-ketoester to nitroalkene: Asymmetric synthesis of (-)-epibatidine

The asymmetric synthesis of 4-nitrocyclohexanone derivatives has been accomplished by enantioselective double Michael additions of γ,δ-unsaturated β-ketoesters to nitroalkenes using a catalytic amount of bifunctional thiourea and TMG. The three contiguous