82026-75-3

Basic information

• Product Name: Ethanone, 1-[3-(fluoromethyl)phenyl]-
• CAS NO: 82026-75-3
• Molecular Formula: C9H9FO
• Molecular Weight: 152.168
• Mol File: 82026-75-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[3-(fluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[3-(fluoromethyl)phenyl]-(82026-75-3)
• EPA Substance Registry System: Ethanone, 1-[3-(fluoromethyl)phenyl]-(82026-75-3)

Safety Data

• Hazardous Substances Data: 82026-75-3(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-[3-(fluoromethyl)phenyl]- is a chemical compound with the molecular formula C9H9FO and a molecular weight of 148.16 g/mol. It is also known by the trade name Flucetosalm and is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a ketone derivative with a fluoromethyl group attached to the phenyl ring, and it is commonly used as a building block in organic synthesis. Ethanone, 1-[3-(fluoromethyl)phenyl]- may have various applications in the pharmaceutical and chemical industries, and it is important to handle it with care due to its potential hazards.

Upstream product

• 373-53-5 fluoroiodomethane 
• 214360-49-3 1-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethanone 
• 82732-06-7 3-(fluoromethyl)phenyllithium 
• 585-74-0 3-Methylacetophenone 

Downstream Products

• 82026-88-8 2-Bromo-2-(3-fluoromethyl-phenyl)-propionitrile 
• 82026-79-7 α-hydroxy-α-methyl-3-(fluoromethyl)benzeneacetonitrile 
• 82026-85-5 α-hydroxy-α-methyl-3-(fluoromethyl)benzeneacetonitrile methanesulfonate 

Relevant articles and documents

Palladium-Catalyzed Monofluoromethylation of Arylboronic Esters with Fluoromethyl Iodide

The first palladium-catalyzed direct monofluoromethylation of arylboronic esters to produce monofluoromethyl arenes is reported. The reaction is typically carried out at room temperature within 4 h and has a good functional group tolerance. The monofluoromethylating agent, CH2FI, was readily prepared via a halogen-exchange process.

Selective electrolytic fluorinations in 70% HF/30% pyridine

The selective fluorination of compounds containing benzylic hydrogen atoms was accomplished by electrolysis in a mixture of 70% HF and 30% pyridine (Olah's reagent) using a square wave alternating current (1.76-2.75 V, 0.02-0.05 Hz) and Pt electrodes. This method can be used in the laboratory to prepare conveniently gram-size quantities of monofluorinated products. An ion radical mechanism has been proposed.