82026-75-3

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-[3-(fluoromethyl)phenyl]is utilized as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic benefits. The presence of the fluoromethyl group on the phenyl ring enhances the compound's reactivity and selectivity in chemical reactions, facilitating the creation of novel pharmaceutical agents.
Used in Agrochemical Industry:
In the agrochemical sector, Ethanone, 1-[3-(fluoromethyl)phenyl]serves as a key intermediate in the production of various agrochemicals. Its incorporation into the molecular structure of these compounds can improve their effectiveness in pest control and crop protection. The fluoromethyl group's influence on the compound's properties may also contribute to the development of more environmentally friendly and targeted agrochemicals.
Used in Organic Synthesis:
Ethanone, 1-[3-(fluoromethyl)phenyl]is a valuable building block in organic synthesis due to its reactivity and the presence of the fluoromethyl group. It can be used to construct a wide range of organic compounds, including those with potential applications in materials science, pharmaceuticals, and agrochemicals. Its versatility in organic synthesis makes it an essential component in the development of new and innovative chemical products.
It is important to handle Ethanone, 1-[3-(fluoromethyl)phenyl]with care due to its potential hazards. Proper safety measures should be taken during its synthesis, storage, and use to minimize risks associated with this chemical compound.

Upstream product

• 585-74-0 3-Methylacetophenone 
• 373-53-5 fluoroiodomethane 
• 214360-49-3 1-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethanone 
• 82732-06-7 3-(fluoromethyl)phenyllithium 

Downstream Products

• 82026-88-8 2-Bromo-2-(3-fluoromethyl-phenyl)-propionitrile 
• 82026-79-7 α-hydroxy-α-methyl-3-(fluoromethyl)benzeneacetonitrile 
• 82026-85-5 α-hydroxy-α-methyl-3-(fluoromethyl)benzeneacetonitrile methanesulfonate 

Relevant academic research and scientific papers

Palladium-Catalyzed Monofluoromethylation of Arylboronic Esters with Fluoromethyl Iodide

The first palladium-catalyzed direct monofluoromethylation of arylboronic esters to produce monofluoromethyl arenes is reported. The reaction is typically carried out at room temperature within 4 h and has a good functional group tolerance. The monofluoromethylating agent, CH2FI, was readily prepared via a halogen-exchange process.

Transition-metal-free C-H oxidative activation: Persulfate-promoted selective benzylic mono- and difluorination

An operationally simple and selective method for the direct conversion of benzylic C-H to C-F to obtain mono- and difluoromethylated arenes using Selectfluor as a fluorine source is developed. Persulfate can be used to selectively activate benzylic hydrogen atoms toward C-F bond formation without the aid of transition metal catalysts.

Selective electrolytic fluorinations in 70% HF/30% pyridine

The selective fluorination of compounds containing benzylic hydrogen atoms was accomplished by electrolysis in a mixture of 70% HF and 30% pyridine (Olah's reagent) using a square wave alternating current (1.76-2.75 V, 0.02-0.05 Hz) and Pt electrodes. This method can be used in the laboratory to prepare conveniently gram-size quantities of monofluorinated products. An ion radical mechanism has been proposed.

Influence of an α-Cyano Function on Charge Delocalization in the Benzyl Cation. Relationship between Inductive Destabilization and Conjugative Stabilization by the Cyano Group

The solvolytic behavior of a series of substituted acetophenone cyanohydrin methanesulfonates has been studied in 2,2,2-trifluoroethanol.A ρ value of -6.70 was observed when the rate data was evaluated vs.Brown's ?+ values.