82033-31-6

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 76726-17-5 (22R)-25,26,27-trisnorcholest-5,23-diene-3β-tetrahydropyranyloxy-22-ol 
• 76719-27-2 (S)-5-{(1R,2S)-2-[(3S,8S,9S,10R,13S,14S,17R)-10,13-Dimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-1-iodo-propyl}-3-methyl-dihydro-furan-2-one 
• 82033-29-2 cholest-5-en-22,23-epoxy-3β-tetrahydropyranyloxy-26-oic acid methyl ester 
• 76719-24-9 (E)-(R)-6-((3S,8S,9S,10R,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-hept-4-enoic acid 
• 76719-25-0 cholest-5-ene-3β-hydroxy-22-iodo-26,23-lactone 
• 76719-23-8 (22E)-cholest-5,22-diene-3β-tetrahydropyranyloxy-26-oic acid ethyl ester 
• 22145-61-5 3β-(tetrahydropyran-2-yloxy)-23,24-dinorchol-5-en-22-al 

Downstream Products

• 17954-98-2 22(R)-Hydroxycholesterol 

Relevant academic research and scientific papers

SYNTHESES OF FOUR ISOMERS OF 25-HYDROXYVITAMIN D3-26,23-LACTONE

A major metabolite of vitamin D3 was recently isolated and identified as 25-hydroxyvitamin D3-26,23-lactone.To determine the configurations at C-23 and C-25 positions, the four stereoisomers were synthesized by stereoselective lactonization method.The two 23R-isomers were obtained by iodolactonization of 22,23-trans-26-acid, and the two 23S-isomers were synthesized by selenolactonization of 22,23-cis-26-acid.The four synthetic isomers and the naturally produced lactone were co-chromatographed on a high performance liquid chromatographic system capable of separating the four isomers.The natural lactone comigrated with synthetic (23S,25R)-isomer determining its structure as (23S,25R)-25-hydroxyvitamin D3-26,23-lactone.