82040-00-4

Upstream product

• 98157-45-0 6-(4-chlorophenyl)-2,2-dimethyl-1,3-dioxin-4-one 
• 95-54-5 1,2-diamino-benzene 
• 25755-85-5 3-(4-chlorophenyl)isoxazol-5-(4H)-one 
• 2881-63-2 ethyl (4-chlorobenzoyl)acetate 
• 58303-62-1 5-(4-chlorophenyl)-2,3-dihydrofuran-2,3-dione 

Downstream Products

• 1337994-41-8 1-benzyl-4-(4-chlorophenyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one 
• 1337994-23-6 1-benzyl-4-(4-chlorophenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one 
• 82040-02-6 3-chloro-4-(p-chlorophenyl)-2,3-dihydro-1H-1,5-benzodiazepin-2-one 

Relevant academic research and scientific papers

Synthesis of 1H-1,5-benzodiazepin-2(3H)-ones from 5(4H)-isoxazolone, a heterocyclic bifunctional C-3 synthon

Unsubstituted and 7- or 8-substituted 4-aryl-1H-1,5-benzodiazepin-2(3H)-ones 3a-t have been synthesized by the condensation of 3-aryl-5(4H)-isoxazolones 1a-e and parent 4-substituted 1,2-benzenediamines 2a-d under acidic conditions.

REACTION OF 2,2-DIMETHYL-6-ARYL-1,3-DIOXIN-4-ONES WITH AROMATIC AMINES AND o-PHENYLENEDIAMINE

N-Arylaroylacetamides and 4-aryl-1,5-benzodiazepin-4-ones were obtained by the thermolysis of 2,2-dimethyl-6-aryl-1,3-dioxin-4-ones in the presence of aromatic amines and o-phenylenediamine respectively.Investigetion of the reaction kinetics showed that the controlling stage is the generation of the aroylketenes, which takes place by a concerted -retrocycloaddition mechanism.

Chloro derivatives of 4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one

The chlorination of 4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one with N-chlorosuccinimide takes place at the methylene group to give mono and diehloro derivatives. In the reaction of the diazepinone with sulfuryl chloride chlorine is incorporated in th